【摘要】：目的探討組蛋白去乙�；敢种苿┓⒅Z他(SAHA)對肺腺癌厄洛替尼(Erlotinib)耐藥細(xì)胞株P(guān)C-9/ER耐藥性的影響。方法 PC-9/ER經(jīng)過厄洛替尼單藥、SAHA單藥、厄洛替尼聯(lián)合SAHA處理48 h后,MTT法檢測各種藥物對PC-9/ER細(xì)胞的增殖抑制率;流式細(xì)胞術(shù)檢測細(xì)胞凋亡率。結(jié)果 SAHA單藥對PC-9/ER具有抑制作用,呈明顯的劑量依賴效應(yīng)關(guān)系。無細(xì)胞毒劑量的SAHA(1μmol/L)能明顯提高PC-9/ER對厄洛替尼的敏感性。結(jié)論 SAHA能夠部分改善PC-9/ER對厄洛替尼的敏感性。
[Abstract]:Objective to investigate the effect of (SAHA), a histone deacetylase inhibitor, on the drug resistance of erlotinib (Erlotinib) resistant lung adenocarcinoma cell line PC-9/ER. Methods after PC-9/ER was treated with erlotinib and SAHA for 48 h, the proliferation inhibition rate of PC-9/ER cells was detected by flow cytometry, and the apoptosis rate was detected by flow cytometry. Results SAHA could inhibit PC-9/ER in a dose-dependent manner. No cytotoxic dose of SAHA (1 渭 mol/L) significantly increased the sensitivity of PC-9/ER to erlotinib. Conclusion SAHA can partially improve the sensitivity of PC-9/ER to erlotinib.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院腫瘤內(nèi)科;
【基金】：安徽省對外科技合作計(jì)劃項(xiàng)目(編號(hào):1503062023)
【分類號(hào)】：R96

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 ;藥品警戒信息[J];中國藥物警戒;2009年09期

2 李華榮;孫W毞，

本文編號(hào)：2169826