【摘要】：通過載體聚乙烯吡咯烷酮(PVPk29/32)和羥丙基甲基纖維素(HPMC),采用溶劑法制備白藜蘆醇(Res)二元及三元固體分散體。用傅里葉變換紅外光譜(FTIR)、調(diào)制式差示掃描量熱(MDSC)和X射線粉末衍射(XRD)等技術(shù)手段來表征Res二元和三元固體分散體并考察其溶出度。FTIR結(jié)果顯示,Res與PVPk29/32及HPMC均存在氫鍵相互作用;溶出結(jié)果表明,二元和三元固體分散體均能提高藥物的溶出度。而XRD和MDSC結(jié)果表明,三元固體分散體的相容性優(yōu)于二元固體分散體;3個(gè)月的加速實(shí)驗(yàn)(40℃,75%RH(relative humidity))中,XRD、MDSC及體外溶出結(jié)果表明,Res三元固體分散體的穩(wěn)定性優(yōu)于Res二元固體分散體。HPMC的加入可以改善Res三元固體分散體的溶出及穩(wěn)定性。
[Abstract]:The binary and ternary solid dispersions of resveratrol (Res) were prepared by solvent method using PVPk29/32 and (HPMC),. Fourier transform infrared spectroscopy (FTIR) (FTIR), modulated differential scanning calorimetry (MDSC) and X-ray powder diffraction (XRD) were used to characterize binary and ternary solid dispersion of Res. The dissolution results showed that both binary and ternary solid dispersions could improve the dissolution of the drug. XRD and MDSC results show that, The compatibility of ternary solid dispersion was superior to that of binary solid dispersion, and the results of three months accelerated experiment (40 鈩，

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