【摘要】：本文用超聲微泡可逆地有限開(kāi)放血腦屏障(blood-brain barrier,BBB),為抗腫瘤藥物的腦內(nèi)靶向遞送打下基礎(chǔ)。建立腦膠質(zhì)瘤大鼠模型,探索低頻超聲(1 MHz)結(jié)合微泡對(duì)腦膠質(zhì)瘤部位BBB開(kāi)放的影響,并與非超聲條件下伊文思藍(lán)(Evans blue,EB)滲透BBB對(duì)比�？疾斐暤臅r(shí)機(jī)和時(shí)長(zhǎng)對(duì)BBB滲透和腦組織的損傷作用�？疾炷X膠質(zhì)瘤生長(zhǎng)期對(duì)BBB滲透性的影響。結(jié)果表明,腦膠質(zhì)瘤對(duì)BBB滲透性影響非常有限;而超聲微泡可短暫有限開(kāi)放BBB,并具有可逆性,可促進(jìn)EB和核磁增強(qiáng)造影劑滲透BBB。超聲時(shí)長(zhǎng)30 s最合適,可開(kāi)放BBB,并且對(duì)腦組織不會(huì)造成明顯損傷。藥物需在超聲前注射才能借助BBB開(kāi)放進(jìn)入腦。超聲微泡可安全有效開(kāi)放BBB,控制時(shí)機(jī)和時(shí)長(zhǎng),能促進(jìn)藥物進(jìn)入腦膠質(zhì)瘤和腦組織。
[Abstract]:In this paper, a reversible and limited opening of the blood brain barrier (BBB) with ultrasound microbubbles was used to lay the foundation for the intracerebral targeting delivery of antitumor drugs. To investigate the effect of low frequency ultrasound (1 MHz) combined with microbubbles on the opening of BBB in brain glioma, the rat model of glioma was established and compared with Evans blue EB osmotic BBB under non ultrasonic conditions. To investigate the time and duration of ultrasound on BBB osmotic and brain tissue damage. To investigate the effect of glioma growth on the permeability of BBB. The results showed that brain glioma had a very limited effect on the permeability of BBB, while ultrasound microbubbles could temporarily and limitedly open BBB, which was reversible and could promote the permeation of EB and nuclear magnetic enhanced contrast agent. The optimal time of ultrasound was 30 s, BBB could be opened, and no obvious damage to brain tissue could be caused. Drugs need to be injected before ultrasound to open into the brain with BBB. Ultrasound microbubbles can open BBB safely and effectively, control time and time, and promote drug entry into brain glioma and brain tissue.
【作者單位】： 溫州醫(yī)科大學(xué);軍事醫(yī)學(xué)科學(xué)院放射與輻射醫(yī)學(xué)研究所;
【基金】：“重大新藥創(chuàng)制”科技重大專(zhuān)項(xiàng)資助項(xiàng)目(2012ZX09301003-001-009) 國(guó)家自然科學(xué)基金資助項(xiàng)目(81360195)
【分類(lèi)號(hào)】：R739.41;R94

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