【摘要】：近年來,納米粒作為藥物載體在藥劑領(lǐng)域得到廣泛應(yīng)用,特別是對一些難溶性和毒副作用大的藥物,設(shè)計出不同的納米藥物載體可以達到增加溶解度和靶向治療目的。納米靶向給藥系統(tǒng)可將藥物特異性遞送到靶部位,實現(xiàn)藥物的控制釋放,從而提高藥物的生物利用度和療效并減少毒副作用。納米粒載體的性質(zhì)不同,其在體內(nèi)的生物效應(yīng)是不同的。筆者對近年來各種聚合物材料制成的納米粒大小,表面性質(zhì)對體內(nèi)的分布影響及常用的納米粒載體在體內(nèi)遇到的障礙,靶向納米粒設(shè)計思路和其生物效應(yīng)的研究進展進行綜述。
[Abstract]:In recent years, nanoparticles as drug carriers have been widely used in the pharmaceutical field, especially for some insoluble and toxic side effects of drugs, the design of different nano-drug carriers can achieve the purpose of increasing solubility and targeting treatment. Nano-targeted drug delivery system can deliver the drug specifically to the target site to achieve the controlled release of drugs, thus improving the bioavailability and efficacy of drugs and reducing side effects. The biological effects of nanoparticles in vivo are different because of their different properties. In this paper, the effects of the size and surface properties of various polymer materials on the distribution of nanoparticles in vivo, the obstacles encountered by common nanoparticles carriers in vivo, the design ideas of targeted nanoparticles and the research progress of their biological effects are reviewed in this paper.
【作者單位】： 延邊大學(xué)附屬醫(yī)院;中國醫(yī)學(xué)科學(xué)院藥物研究所;
【分類號】：R943
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本文編號：2128007