發(fā)布時(shí)間：2018-07-03 17:21

  本文選題：可溶性微針 + 材料分類�。� 參考：《材料導(dǎo)報(bào)》2017年19期

【摘要】：可溶性微針作為新型透皮給藥制劑,打破了傳統(tǒng)皮膚給藥制劑不能用于大分子藥物經(jīng)皮給藥的局限,且具有無(wú)痛、無(wú)創(chuàng)、無(wú)出血、衛(wèi)生、生物相容性好、便于患者自主使用等諸多優(yōu)點(diǎn)。近年來(lái)可溶性微針的研究已成為備受關(guān)注的熱點(diǎn)。基質(zhì)材料的選擇直接影響微針的制備及皮膚刺入、藥物釋放等性能。介紹了可溶性微針的研究現(xiàn)狀,對(duì)基質(zhì)材料進(jìn)行了分類與介紹,并綜述了基質(zhì)材料的復(fù)合使用及效果。同時(shí)介紹了韌性材料和脆性材料的特性及其復(fù)合后的協(xié)同效果,進(jìn)而對(duì)該領(lǐng)域存在的問(wèn)題和研究方向進(jìn)行了討論和展望。
[Abstract]:Soluble microneedle, as a new transdermal drug delivery agent, breaks the limitation that traditional skin drug delivery can not be used for transdermal drug delivery of macromolecular drugs, and has painless, non-invasive, non-bleeding, sanitary and good biocompatibility. It is convenient for patients to use independently and so on. In recent years, the research of soluble microneedles has become a hot spot. The choice of matrix material directly affects the preparation of microneedles, skin penetration, drug release and other properties. This paper introduces the research status of soluble microneedles, classifies and introduces the matrix materials, and summarizes the composite use and effect of the matrix materials. At the same time, the properties of ductile and brittle materials and their synergistic effects after compounding are introduced, and the existing problems and research directions in this field are discussed and prospected.
【作者單位】： 浙江工業(yè)大學(xué)藥學(xué)院生物制劑與材料實(shí)驗(yàn)室;
【基金】：浙江省重點(diǎn)科技創(chuàng)新團(tuán)隊(duì)項(xiàng)目(2013TD15)
【分類號(hào)】：R943
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本文編號(hào)：2094377