本文選題：生物可降解高分子納米載體 + 抗腫瘤藥物　； 參考：《江西農(nóng)業(yè)大學(xué)》2014年碩士論文

【摘要】：隨著社會(huì)的高速發(fā)展,人們的生活壓力變大,生存環(huán)境也變得惡劣,這些都造成了癌癥的高發(fā),嚴(yán)重威脅人類健康。在人類對(duì)抗癌癥的手段中化療是其中很重要的一部分,普通化療藥物如阿霉素、紫杉醇、順鉑等不僅體內(nèi)半衰期短,生物利用度低,而且腫瘤靶向性不強(qiáng)無法有效聚集在病灶部位這些都導(dǎo)致了化療效果不佳、毒副作用大,易產(chǎn)生耐藥性,嚴(yán)重影響了病人的治療和生活質(zhì)量。為了解決這些問題,我們利用生物相容性好、生物降解的高分子材料設(shè)計(jì)制備了納米藥物輸送體系對(duì)這些化療藥物進(jìn)行擔(dān)載和腫瘤靶向輸送,同時(shí)我們還用這些高分子材料來擔(dān)載造影劑,借助新進(jìn)光聲成像技術(shù)(MSOT)考察腫瘤模型及粒徑大小對(duì)納米藥物生物分布和代謝的影響為以后的個(gè)性化治療做些基礎(chǔ)研究。具體如下： 1.設(shè)計(jì)合成了聚乙二醇聚谷氨酸嵌段共聚物,并在該高分子納米載體上擔(dān)載紫杉醇與阿霉素這兩種抗腫瘤藥形成納米共載體系,隨后考察了該納米共載藥體系的相關(guān)理化性質(zhì)及體外細(xì)胞毒性,體內(nèi)抑瘤活性得到了比較滿意的結(jié)果。 2.利用聚乙二醇聚乳酸(PDLLA)納米粒子擔(dān)載近紅外熒光染料吲哚青綠(ICG),通過改變投料比大小來制作出不同粒徑的擔(dān)載ICG的納米粒子,然后借助新進(jìn)的無損光聲成像技術(shù)(MSOT)來觀察這些不同粒徑的納米粒子在體內(nèi)的代謝及聚集情況。 通過本論文的一些工作,希望可以為生物可降解高分子納米載藥體系進(jìn)行癌癥的聯(lián)合治療及個(gè)體化治療研究提供一些思路和基礎(chǔ)研究。
[Abstract]:With the rapid development of society, people's living pressure and living environment become worse, which results in a high incidence of cancer and a serious threat to human health. Chemotherapy is a very important part of human anti-cancer methods. Common chemotherapy drugs, such as adriamycin, paclitaxel and cisplatin, not only have a short half-life in vivo, but also have low bioavailability. Moreover, the weak targeting of tumor can not be effectively concentrated in the focus which leads to the poor effect of chemotherapy, large toxic side effects, easy to produce drug resistance, which seriously affects the treatment and quality of life of patients. In order to solve these problems, we designed and prepared nanopharmaceutical delivery systems using biocompatible and biodegradable polymer materials to support and target these chemotherapeutic agents. At the same time, we also use these polymer materials to support contrast agents, and investigate the effects of tumor model and particle size on the biological distribution and metabolism of nanopharmaceuticals by means of new photoacoustic imaging (MSOT). The details are as follows: 1. Poly (ethylene glycol) poly (glutamic acid) block copolymers were designed and synthesized. Paclitaxel and adriamycin were supported on the polymer nano-carrier to form nano-co-loading system. Then the physicochemical properties and cytotoxicity of the nano-cocarrier system in vitro were investigated, and the results of tumor inhibition in vivo were satisfactory. 2. Using polyethylene glycol polylactic acid (PDLLA) nanoparticles loaded with near infrared fluorescent dye indocyanine green (ICG), different size ICG nanoparticles were prepared by changing the feeding ratio. Then the metabolism and aggregation of these nanoparticles with different particle sizes in vivo were observed by new nondestructive photoacoustic imaging (MSOT). Through some work in this paper, we hope to provide some ideas and basic research for the combination therapy and individualized treatment of cancer with biodegradable polymer nano-drug carrier system.
【學(xué)位授予單位】：江西農(nóng)業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R943

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