本文選題：阿苯達(dá)唑納米脂質(zhì)體凍干粉 + 大鼠��； 參考：《中國醫(yī)院藥學(xué)雜志》2017年08期

【摘要】：目的:研究阿苯達(dá)唑納米脂質(zhì)體凍干粉在大鼠體內(nèi)的藥動學(xué)過程及肝臟靶向性。方法:大鼠以灌胃給予阿苯達(dá)唑片、阿苯達(dá)唑脂質(zhì)體及阿苯達(dá)唑納米脂質(zhì)體凍干粉,分別于給藥后不同時間點取血及肝臟,樣品預(yù)處理后利用高效液相色譜(HPLC)法測定血漿及肝組織中藥物濃度,考察3種制劑的藥動學(xué)參數(shù)及肝靶向性差異。結(jié)果:阿苯達(dá)唑納米脂質(zhì)體凍干粉主要藥動學(xué)參數(shù)如下:C_(max)為(7.05±0.70)μg·mL~(-1),t_(max)為(6.15±0.66)h,AUC_(0-∞)為(150.9±12.1)μg·mL~(-1)·h,以阿苯達(dá)唑片、阿苯達(dá)唑脂質(zhì)體為參比制劑,阿苯達(dá)唑納米脂質(zhì)體凍干粉相對生物利用度分別為236.04%和178.45%;肝靶向試驗結(jié)果顯示:阿苯達(dá)唑納米脂質(zhì)體凍干粉在肝組織中的分布顯著高于阿苯達(dá)唑片和阿苯達(dá)唑脂質(zhì)體。結(jié)論:將阿苯達(dá)唑脂質(zhì)體制成納米級脂質(zhì)體凍干粉后,可顯著提高藥物的相對生物利用度和肝靶向性。
[Abstract]:Aim: to study the pharmacokinetics and liver targeting of albendazole nano-liposome freeze-dried powder in rats. Methods: albendazole tablets, albendazole liposome and albendazole nano-liposome freeze-dried powder were administered to rats by gavage. Blood and liver were collected at different time points after administration. After pretreatment, the concentrations of drugs in plasma and liver tissue were determined by HPLC, and the pharmacokinetic parameters and liver targeting properties of the three preparations were investigated. Results: the main pharmacokinetic parameters of albendazole nano-liposome freeze-drying powder were as follows: C _ (max) was (7.05 鹵0.70) 渭 g mL ~ (-1) (max) was (6.15 鹵0.66) h AUC _ (0- 鈭，

本文編號：2090664