本文選題：伊潘立酮 + 含量��； 參考：《中國藥師》2016年12期

【摘要】：目的:建立伊潘立酮的含量及有關(guān)物質(zhì)測定方法。方法:采用HPLC法,色譜柱:VP-ODS C18柱(150 mm×4.6 mm,5μm);流動相:甲醇-0.1 mol·L~(-1)磷酸氫二銨溶液(用磷酸調(diào)pH至6.2±0.1)(65∶35);流速:1.0 ml·min~(-1);檢測波長:275nm和228 nm;柱溫:30℃;進樣量:20μl。結(jié)果:本方法能較好地分離伊潘立酮及其有關(guān)物質(zhì),伊潘立酮在10.08~100.80μg·ml~(-1)濃度范圍內(nèi)線性關(guān)系良好(r=0.999 8),平均回收率為100.2%(RSD=0.82%,n=9)。結(jié)論:該方法靈敏快速、結(jié)果準確、重復(fù)性好,可用于伊潘立酮原料藥的含量測定及有關(guān)物質(zhì)檢查。
[Abstract]:Objective: to establish a method for the determination of the content and related substances of peridone. Methods: using HPLC method, chromatographic column: VP-ODS C18 column (150 mm x 4.6 mm, 5 micron m); mobile phase: methanol -0.1 mol. L~ (-1) dihydrogen phosphate solution (pH to 6.2 + 0.1) (65: 35); flow velocity: 1 ml. 228; column temperature: 30 C; sampling amount: 20 micron Results: the method was good for isolating peridone and its related substances. The linear relationship of peridone in the concentration range of 10.08~100.80 mu g. Ml~ (-1) was good (r=0.999 8). The average recovery rate was 100.2% (RSD=0.82%, n=9). Conclusion: the method is sensitive, rapid, accurate and reproducible. It can be used for the determination of the content of apperrisone and the related content of the drug. Physical examination.
【作者單位】： 武漢大學(xué)中南醫(yī)院藥學(xué)部;
【分類號】：R927.2;O657.72

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