本文選題：抗癌肽 + 抗癌肽來源��； 參考：《生物技術通報》2017年11期

【摘要】：隨著全球癌癥患病比例的逐年增加,癌癥已經(jīng)成為全球死亡的主要原因和重大的公共衛(wèi)生問題�？拱╇哪芷茐哪[瘤細胞膜結(jié)構(gòu)或抑制癌細胞增殖和遷移以及腫瘤血管的形成,幾乎不表現(xiàn)溶血性且對正常的人體細胞基本無損傷等優(yōu)點,已經(jīng)成為抗腫瘤新藥研究的一大熱點�？拱╇闹饕獊碓纯煞譃�4類:抗菌肽類如牛乳鐵蛋白肽(Lfcin B)、天蠶素等,對細菌等微生物具有廣譜高效的抑制活性,同時能夠抑制多種癌細胞的增殖和生長,誘導癌細胞凋亡;多肽激素類如心房利鈉肽(ANP)以及在ANP形成過程中的其他一些多肽,在臨床上具有增加血管通透性、降壓、利鈉、利尿、舒張血管平滑肌、調(diào)節(jié)水鹽平衡和抑制細胞增殖等作用,最近研究發(fā)現(xiàn)它們可以直接殺死腫瘤細胞或強力抑制癌細胞DNA的合成,從而抑制癌細胞的生長;多肽毒素類如蜂毒、蛇毒、蝎毒等毒性較強的生物毒素,對多種腫瘤均有抑制作用;內(nèi)皮抑制素可以抑制腫瘤血管的生成抑制癌細胞的生長和轉(zhuǎn)移�？拱╇闹饕ㄟ^誘導細胞凋亡、破壞細胞的膜結(jié)構(gòu),改變細胞周圍或細胞內(nèi)p H以及增強免疫應答等多種機制來抑制癌細胞增殖。綜述抗癌肽的來源、抑癌機理,并對抗癌肽的應用前景進行分析,旨為抗癌肽的深入研究和開發(fā)應用提供參考。
[Abstract]:With the increasing incidence of cancer worldwide, cancer has become a major cause of death and a major public health problem. Anticancer peptides can destroy the structure of tumor cell membrane or inhibit the proliferation and migration of cancer cells, as well as the formation of tumor blood vessels, almost no hemolysis and no damage to normal human cells, which has become a hot spot in the research of new anti-tumor drugs. The main sources of anticancer peptides can be divided into four categories: antimicrobial peptides, such as lactoferrin Bu, daponin, have broad-spectrum and high efficiency inhibitory activity against bacteria and other microorganisms, and can inhibit the proliferation and growth of many kinds of cancer cells and induce apoptosis of cancer cells; Peptide hormones such as atrial natriuretic peptide (ANPP) and other peptides in the formation of ANP have the effects of increasing vascular permeability, lowering blood pressure, natriuretic, diuretic, relaxing vascular smooth muscle, regulating water and salt balance and inhibiting cell proliferation, etc. Recent studies have found that they can directly kill tumor cells or strongly inhibit the synthesis of DNA from cancer cells, thereby inhibiting the growth of cancer cells; polypeptide toxins such as bee venom, snake venom, scorpion venom and other highly toxic biotoxins, Endothelin inhibits the angiogenesis of tumor and inhibits the growth and metastasis of cancer cells. Anticancer peptides inhibit the proliferation of cancer cells by inducing cell apoptosis, destroying cell membrane structure, changing pH around or within cells and enhancing immune response. The origin and mechanism of anticancer peptides are reviewed, and the application prospect of anticancer peptides is analyzed in order to provide reference for further research and development of anticancer peptides.
【作者單位】： 武漢生物工程學院藥學院;湖北工業(yè)大學生物工程與食品學院發(fā)酵工程教育部重點實驗室;華南農(nóng)業(yè)大學生命科學學院;
【基金】：國家自然科學基金青年基金項目(31302148) 湖北省自然科學基金(面上項目) 湖北省教育廳科研項目(B2016302)
【分類號】：R979.1

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