本文選題：姜黃素 + 微乳法��； 參考：《中國藥房》2015年19期

【摘要】：目的:制備姜黃素固體脂質納米粒。方法:微乳法制備姜黃素固體脂質納米粒。采用偽三元相圖法優(yōu)選微乳三相因素,確定優(yōu)化條件后,將熱微乳分散于冷水中制備固體脂質納米粒。單因素試驗初篩各因素(乳化劑、脂質材料、脂質用量、藥脂比、冷水相溫度和微乳保溫溫度)后,以包封率為指標進行正交試驗優(yōu)化處方,并進行驗證試驗。結果:65℃下由硬脂酸(油相)、聚山梨酯80(乳化劑)、乙醇(助乳化劑)組成三相,乳化劑與助乳化劑比為1∶4所制得的微乳最佳。固體脂質納米粒的優(yōu)化處方為姜黃素投藥量為50 mg、硬脂酸的用量為0.5 g、冷水相溫度為2℃、微乳保溫溫度為65℃;所得固體脂質納米粒的包封率為87.73%、載藥量為7.72%、粒徑為(156.9±2.2)nm、多分散系數(shù)為0.480,平均Zeta電位為-24.8 m V(RSD2%,n=3)。結論:采用微乳法制備固體脂質納米粒操作簡便、可行。
[Abstract]:Objective: to prepare curcumin solid lipid nanoparticles. Methods: curcumin solid lipid nanoparticles were prepared by microemulsion method. Three phase factors of microemulsion were selected by pseudo-ternary phase diagram method. After determining the optimum conditions, the thermal microemulsion was dispersed in cold water to prepare solid lipid nanoparticles. After screening the factors (emulsifier, lipid material, lipid dosage, ratio of drug to lipid, cold water phase temperature and microemulsion holding temperature), the encapsulation efficiency was optimized by orthogonal test and the validation test was carried out. Results the microemulsion was composed of stearic acid (oil phase), polysorbate 80 (emulsifier) and ethanol (co-emulsifier) at 65 鈩，

本文編號：2019899