本文選題：細(xì)胞膜修飾 + 納米粒��； 參考：《中國醫(yī)藥工業(yè)雜志》2017年01期

【摘要】：近年來,以納米粒為載體的遞藥系統(tǒng)研究取得了較大進(jìn)展,然而納米粒在體內(nèi)會(huì)產(chǎn)生免疫原性和納米毒性。因此,細(xì)胞膜作為一種更安全有效的載體已成為藥物傳遞領(lǐng)域的研究熱點(diǎn)。將細(xì)胞膜與納米粒進(jìn)行結(jié)合,不僅能增加納米粒的生物相容性,還可以通過選擇不同種類細(xì)胞膜,如血細(xì)胞、干細(xì)胞或細(xì)菌細(xì)胞等,使納米粒獲得靶向性、不易被免疫系統(tǒng)識(shí)別且能延長體循環(huán)時(shí)間等多種生物學(xué)特性。本文介紹了具有生物偽裝功能的細(xì)胞膜修飾納米粒的制備方法、特性和應(yīng)用,以期促進(jìn)納米粒在藥物傳遞領(lǐng)域的應(yīng)用。
[Abstract]:In recent years, great progress has been made in the research of drug delivery system based on nanoparticles. However, nanoparticles can produce immunogenicity and nano-toxicity in vivo. Therefore, cell membrane as a safer and more effective carrier has become a research hotspot in the field of drug delivery. The combination of cell membrane and nanoparticles not only increases the biocompatibility of nanoparticles, but also enables the nanoparticles to be targeted by selecting different types of cell membranes, such as blood cells, stem cells or bacterial cells. It is difficult to be recognized by the immune system and can prolong the body circulation time and other biological characteristics. The preparation, characteristics and application of membrane modified nanoparticles with biological camouflage were introduced in this paper, in order to promote the application of nanoparticles in the field of drug delivery.
【作者單位】： 南京工業(yè)大學(xué)藥學(xué)院;南京百思福醫(yī)藥科技有限公司;
【分類號(hào)】：R943

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本文編號(hào)：2002402