本文選題：西酞普蘭 + 代謝產(chǎn)物　； 參考：《中國新藥雜志》2017年22期

【摘要】：目的:建立西酞普蘭及其代謝產(chǎn)物(去甲基西酞普蘭及二去甲基西酞普蘭)的高效毛細(xì)管電泳手性拆分方法。方法:以磺酸化-β-環(huán)糊精為手性選擇試劑對(duì)西酞普蘭及其代謝產(chǎn)物進(jìn)行拆分,并考察了S-β-CD濃度、背景電解質(zhì)的pH、有機(jī)溶劑的比例對(duì)手性分離的影響。結(jié)果:在pH為3.0,30 mmol·L-1磷酸二氫鈉緩沖溶液,S-β-CD濃度為10 mg·m L-1,有機(jī)溶劑甲醇的濃度為30%,分離電壓為20 k V,檢測波長為205 nm,西酞普蘭及其2個(gè)代謝產(chǎn)物均達(dá)到完全分離,其分離度分別為7.2,6.3,3.4。結(jié)論:該方法簡便、快速,可用于西酞普蘭、去甲基西酞普蘭及二去甲基西酞普蘭的手性分離。
[Abstract]:Objective: to establish a chiral separation method of citalopram and its metabolites (demethylcitalopram and dimethylcitalopram) by high performance capillary electrophoresis (HPCE). Methods: citalopram and its metabolites were separated with sulfonated 尾 -cyclodextrin as chiral selective reagent. The effects of concentration of S- 尾 -CD, pH of background electrolyte and proportion of organic solvent on chiral separation were investigated. Results: the concentration of S- 尾 -CD in sodium dihydrogen phosphate buffer solution was 10 mg mL ~ (-1) at pH 3.0 ~ 30 mmol ~ (-1), the concentration of organic solvent methanol was 30 鈩，

本文編號(hào)：1990423