本文選題：他汀類藥物 + 心臟舒張功能　； 參考：《中國臨床藥理學(xué)雜志》2015年07期

【摘要】：目的評(píng)價(jià)他汀類藥物治療對(duì)心臟舒張功能及運(yùn)動(dòng)后血漿腦利鈉肽(BNP)水平的影響。方法隨機(jī)將60例心臟舒張功能不全合并運(yùn)動(dòng)高血壓患者分成阿托伐他汀治療組和對(duì)照組各30例。在原有治療基礎(chǔ)上,治療組加用阿托伐他汀20 mg,每晚1次,對(duì)照組則加用安慰劑,療程1年。測定治療前后患者的心功能、運(yùn)動(dòng)心肺功能和運(yùn)動(dòng)后血漿BNP濃度。結(jié)果治療后,治療組的二尖瓣血流頻譜E峰與A峰比值(E/A)有明顯改善,運(yùn)動(dòng)時(shí)間延長,運(yùn)動(dòng)當(dāng)量、運(yùn)動(dòng)最大攝氧量、無氧閾值均明顯增大,運(yùn)動(dòng)BNP明顯下降,與治療前相比差異均有統(tǒng)計(jì)學(xué)意義(P0.05);治療后與對(duì)照組相比,E/A、運(yùn)動(dòng)時(shí)間、運(yùn)動(dòng)BNP濃度差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論阿托伐他汀治療能改善心臟舒張功能,降低運(yùn)動(dòng)BNP水平,提高運(yùn)動(dòng)耐量。
[Abstract]:Objective to evaluate the effects of statins on cardiac diastolic function and plasma brain natriuretic peptide (BNP) levels after exercise. Methods 60 patients with diastolic dysfunction associated with exercise hypertension were randomly divided into two groups: Atto vastatin group (n = 30) and control group (n = 30). On the basis of the original treatment, the treatment group was treated with Atto vastatin 20 mg once a night, while the control group was treated with placebo for one year. Heart function, cardiopulmonary function and plasma BNP concentration were measured before and after treatment. Results after treatment, the ratio of E peak to A peak of mitral flow spectrum in the treatment group was significantly improved, the exercise time was prolonged, the exercise equivalent, the maximal oxygen uptake of exercise, the anaerobic threshold, and the BNP of exercise were obviously increased. Compared with the control group, the difference of E / A, exercise time and BNP concentration after treatment was statistically significant (P 0.05). Conclusion the treatment of Atto vastatin can improve cardiac diastolic function, decrease the level of exercise BNP and improve exercise tolerance.
【作者單位】： 金華廣福醫(yī)院心內(nèi)科;浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院心內(nèi)科;
【基金】：金華市自然科學(xué)基金資助項(xiàng)目(2010-3-028)
【分類號(hào)】：R969

【共引文獻(xiàn)】

相關(guān)期刊論文 前1條

1 陳航;盧聰;閆亞非;;他汀類藥物在冠心病治療中的多效性[J];現(xiàn)代臨床醫(yī)學(xué);2013年05期

相關(guān)碩士學(xué)位論文 前1條

1 王丹;老年左室舒張功能不全的回顧性分析[D];首都醫(yī)科大學(xué);2013年

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 高中秋,陳永紅,李萬鎮(zhèn);心臟舒張功能的研究進(jìn)展[J];中華兒科雜志;1997年09期

2 張麗華,房丹s，

本文編號(hào)：1977259