本文選題：聚桂醇 + 泡沫硬化劑　； 參考：《山東大學(xué)》2017年碩士論文

【摘要】：背景:脈管畸形好發(fā)于頸面部,是一種由于胚胎時(shí)期脈管的錯(cuò)誤發(fā)育而形成的血管或者淋巴管系統(tǒng)的先天性疾病。依據(jù)構(gòu)成脈管畸形的管道成分的不同又分為淋巴管畸形、微靜脈畸形、靜脈畸形、動(dòng)脈畸形、動(dòng)靜脈畸形以及混合畸形。隨著科學(xué)技術(shù)發(fā)展和藥物的研發(fā),脈管畸形的治療方法豐富多樣,現(xiàn)階段臨床常用的治療方法有手術(shù)切除、激光照射、硬化治療及多種方式的聯(lián)合治療等。近年來(lái),泡沫硬化劑血注射因其具有操作簡(jiǎn)單、療效佳的特點(diǎn),逐漸成為脈管畸形的重要治療方法。與傳統(tǒng)的液體硬化劑相比,泡沫硬化劑因其具有泡沫性,從而臨床應(yīng)用中具有硬化劑用量少,硬化作用時(shí)間長(zhǎng),療效顯著,并發(fā)癥少等優(yōu)點(diǎn)。泡沫硬化劑的穩(wěn)定性對(duì)其硬化效果具有重要影響,并與術(shù)后相關(guān)并發(fā)癥的產(chǎn)生有重要關(guān)系。泡沫硬化劑的穩(wěn)定性問(wèn)題得到了臨床醫(yī)生的關(guān)注。大量研究發(fā)現(xiàn),泡沫硬化劑穩(wěn)定性與硬化劑性質(zhì)、制備方法、液氣比等因素有關(guān),有學(xué)者研究發(fā)現(xiàn)低溫可以增加泡沫的穩(wěn)定性;泡沫的制備速度可能與硬化劑的穩(wěn)定性有關(guān)。聚桂醇注射液作為臨床治療中廣泛用于制作泡沫硬化劑的藥物,其制備的泡沫穩(wěn)定性與臨床治療效果有重要聯(lián)系,但溫度和制備速度與聚桂醇泡沫的穩(wěn)定性的關(guān)系尚不明確。目的:1.通過(guò)研究不同溫度下聚桂醇泡沫的半衰期變化情況,探討溫度變化對(duì)泡沫硬化劑穩(wěn)定性的影響。通過(guò)對(duì)泡沫制備前行溫度處理與泡沫制備后行溫度處理所獲的泡沫半衰期值進(jìn)行統(tǒng)計(jì)分析,研究溫度處理方式對(duì)泡沫硬化劑穩(wěn)定性的影響。2.通過(guò)研究不同制備速度獲得的泡沫半衰期的變化情況,探討制備速度與泡沫硬化劑穩(wěn)定性的相關(guān)性。方法:1.溫度變化對(duì)聚桂醇泡沫穩(wěn)定性的影響將實(shí)驗(yàn)分為2組:預(yù)處理組—將盛有聚桂醇注射液的注射器及盛有空氣的注射器通過(guò)醫(yī)用三通管連接后,置于不同溫度中(5、15、25、35、45、55和65℃),預(yù)處理10min后,根據(jù)Tessari法制備聚桂醇泡沫。記錄泡沫在室溫(T=25℃)條件下的半衰期;后處理組—先在室溫條件下制備聚桂醇泡沫,然后記錄泡沫在不同溫度下(5、15、25、35、45、55和65℃)的半衰期。利用SPSS 19.0軟件包進(jìn)行統(tǒng)計(jì)學(xué)分析,應(yīng)用Pearson相關(guān)性檢驗(yàn),分析各處理組中溫度與泡沫半衰期的相關(guān)性;并采用獨(dú)立樣本t檢驗(yàn)研究2組之間即溫度處理方式對(duì)泡沫半衰期的影響。2.制備速度對(duì)聚桂醇泡沫穩(wěn)定性的影響將盛有聚桂醇注射液的注射器及盛有空氣的注射器通過(guò)三通管連接,選用5組不同的推注速度在室溫下制備聚桂醇泡沫,并記錄環(huán)境溫度為25℃條件下的泡沫半衰期值,利用SPSS 19.0軟件包進(jìn)行統(tǒng)計(jì)學(xué)分析,通過(guò)Pearson相關(guān)性檢驗(yàn),分析泡沫制備速度對(duì)泡沫穩(wěn)定性的影響。結(jié)果:1.在預(yù)處理組和后處理組中,溫度變化與聚桂醇泡沫的半衰期之間均存在負(fù)相關(guān)性(預(yù)處理組:r =-0.984,P0.05;后處理組:r=-0.969,P0.05)。T=25℃時(shí),預(yù)處理組與后處理組之間的泡沫半衰期無(wú)顯著差異(P=0.4280.05);T25℃時(shí),預(yù)處理組半衰期高于后處理組;T25℃時(shí),預(yù)處理組半衰期低于后處理組,差異具有顯著性(P0.05)。2.不同制備速度獲得的硬化劑泡沫的半衰期存在差異,通過(guò)統(tǒng)計(jì)學(xué)分析發(fā)現(xiàn),隨著制備速度的增加,泡沫的半衰期逐漸增加(r =0.983,P0.05)。當(dāng)推注速度達(dá)到本實(shí)驗(yàn)最大值(10s/20次)時(shí),硬化劑泡沫的半衰期最長(zhǎng)。結(jié)論:1.溫度是影響聚桂醇泡沫穩(wěn)定性的一個(gè)重要因素,低溫預(yù)處理和低溫環(huán)境均可以提高泡沫的穩(wěn)定性;泡沫制備前的溫度與制備后的環(huán)境溫度對(duì)泡沫穩(wěn)定性的影響存在差異。2.硬化劑泡沫的制備速度對(duì)其穩(wěn)定性具有顯著影響,增加制備速度可以提高硬化劑泡沫的穩(wěn)定性。
[Abstract]:Background: vascular malformation occurs well in the neck and face. It is a congenital disease of the vascular or lymphatic system caused by the incorrect development of the vasculature in the embryonic period. According to the different components of the vascular malformation, it is divided into lymphatic malformation, microvenous malformation, venous malformation, arteriovenous malformation, arteriovenous malformation, and mixed malformation. With the development of science and technology and drug development, the treatment methods of vascular malformation are rich and varied. At the present stage, the commonly used clinical treatment methods are surgical excision, laser irradiation, sclerotherapy and multiple ways of combined treatment. In recent years, the blood injection of foam sclerosing agent has gradually become an important part of the vascular malformation because of its simple operation and good curative effect. Compared with the traditional liquid sclerosing agent, the foam sclerosing agent has the advantages of little dosage of sclerosing agent, long hardening time, significant effect and less complications in clinical application. The stability of the foam sclerosing agent has an important influence on its hardening effect and is important to the production of related complications after the operation. A large number of studies have found that the stability of the foam sclerosing agent is related to the properties of the sclerosing agent, the preparation method, the ratio of liquid to gas, and other factors. Some scholars have found that low temperature can increase the stability of the foam; the preparation speed of the foam may be related to the stability of the sclerosing agent. Polyol injection As a drug widely used in the preparation of foamy sclerosing agents in clinical treatment, the stability of the prepared foam is closely related to the effect of clinical treatment, but the relationship between temperature and preparation speed and the stability of polyol foam is not clear. Objective: 1. the change of the half-life of polyol foam at different temperatures was studied and the temperature change was discussed. Influence on the stability of foamed sclerosing agent. By statistical analysis of the half-life value of foam by temperature treatment and foam preparation after preparation of foam, the influence of temperature treatment on the stability of the foam hardening agent.2. is discussed by studying the change of the half life of foam by studying the different preparation speed. The correlation between the preparation speed and the stability of the foam sclerosing agent. Methods: the effects of 1. temperature changes on the stability of polyol foam were divided into 2 groups: the pretreatment group - the syringes of the polyol injection and the syringes filled with air were connected through the medical three tube, and were placed at different temperatures (5,15,25,35,45,55 and 65 degrees C) and pretreated 1 After 0min, polyol foam was prepared by Tessari method. The half-life of foam at room temperature (T=25) was recorded. The post treatment group first prepared polyol foam at room temperature, and then recorded the half-life of foam at different temperatures (5,15,25,35,45,55 and 65 C). Statistical analysis was carried out by SPSS 19 software package, and Pearson correlation was applied. Test, the correlation between temperature and foam half life in each treatment group was analyzed, and an independent sample t test was used to study the effect of temperature treatment between 2 groups on the half-life of foam. The effect of.2. preparation speed on the stability of polyol foam would be connected by the syringe of the polyol injection and the syringe with the air in the three tube. Polyol foams were prepared at room temperature with 5 different groups of push and injection at room temperature, and the half-life value of the foam was recorded at ambient temperature of 25. SPSS 19 software package was used for statistical analysis. The effect of foam preparation speed on foam stability was analyzed by Pearson correlation test. Results: 1. in the pretreatment group and the post treatment group, temperature There was a negative correlation between the change and the half-life of polyol foam (pre treatment group: R =-0.984, P0.05; r=-0.969, P0.05) at.T=25 C, there was no significant difference in the half life of the foam between the pretreatment group and the post treatment group (P=0.4280.05); at T25, the half life of the pre treated group was higher than that of the post treatment group; at T25, the half-life of the pretreated group was low. In the post treatment group, the half-life of the sclerosing agent of the different preparation speed of the difference (P0.05).2. was different. Through statistical analysis, the half-life of the foam increased gradually (R =0.983, P0.05) with the increase of preparation speed. The half-life of the sclerosing agent when the injection velocity reached the maximum value of the experiment (10s/20 times). Conclusion: 1. temperature is an important factor affecting the stability of polyol foam. Low temperature pretreatment and low temperature environment can improve the stability of foam. There is a difference between the temperature of the foam before preparation and the ambient temperature of the prepared foam on the stability of the foam. The preparation speed of the.2. sclerosing agent has a significant influence on the stability of the foam. Increasing the speed of preparation can improve the stability of hardener foam.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R943

【相似文獻(xiàn)】

相關(guān)會(huì)議論文 前10條

1 李鈺;羅詠萍;陳揚(yáng);;硬化劑治療食管靜脈曲張破裂出血臨床分析[A];中華醫(yī)學(xué)會(huì)第七次全國(guó)消化病學(xué)術(shù)會(huì)議論文匯編（下冊(cè)）[C];2007年

2 鄭琳靜;楊Z，

本文編號(hào)：1966229