本文選題：殼聚糖 + 京尼平�。� 參考：《南方醫(yī)科大學(xué)學(xué)報》2015年06期

【摘要】：目的制備一種包載普伐他汀鈉,以獲得長效釋放的載藥微球。方法以京尼平為交聯(lián)劑制備載普伐他汀鈉的殼聚糖微球,考察殼聚糖相對分子質(zhì)量、油相水相比、反應(yīng)溫度、攪拌速度等對殼聚糖微球形成的影響,通過掃描電鏡觀察其微觀形貌,測定微球的包封率以及不同p H條件下的溶脹度,并考察了普伐他汀鈉的體外累積釋藥情況。結(jié)果載普伐他汀鈉藥微球體外釋放時間長達(dá)31 d以上,反應(yīng)條件不同,藥物釋放速度不同,普伐他汀的包封率可達(dá)54.7%。最佳制備條件為:殼聚糖的粘度為200~400 m Pa.s,油水比10∶1,攪拌速度850 r/min,溫度40℃。結(jié)論京尼平交聯(lián)載普伐他汀鈉的殼聚糖微球具有較好的長效緩釋能力,并且可通過調(diào)節(jié)交聯(lián)時間控制其對藥物的釋放速度。
[Abstract]:Objective to prepare an encapsulated pravastatin sodium for long-term release of drug-loaded microspheres. Methods chitosan microspheres loaded with pravastatin sodium were prepared by using geniapine as crosslinking agent. The effects of relative molecular weight of chitosan, oil phase water ratio, reaction temperature and stirring speed on the formation of chitosan microspheres were investigated. The micromorphology of the microspheres was observed by scanning electron microscope. The entrapment efficiency of the microspheres and the swelling degree under different pH conditions were measured. The cumulative release of pravastatin sodium in vitro was also investigated. Results the release time of pravastatin sodium microspheres in vitro was more than 31 days. The encapsulation efficiency of pravastatin could reach 54.7% with different reaction conditions and different drug release rate. The optimum preparation conditions are as follows: the viscosity of chitosan is 200 ~ 400m Pa. S, the ratio of oil to water is 10: 1, the stirring speed is 850 r / min, the temperature is 40 鈩，

本文編號：1927536