本文選題：創(chuàng)傷性腦損傷 + 丙泊酚　； 參考：《中國(guó)臨床藥理學(xué)雜志》2017年18期

【摘要】：目的觀(guān)察丙泊酚麻醉對(duì)創(chuàng)傷性腦損傷大鼠(TBI)的影響。方法用Feeney法建立TBI模型。按照體重將雄性Wistar大鼠分為4組:假手術(shù)組、模型組和低高2個(gè)劑量實(shí)驗(yàn)組,每組20只。低高2個(gè)劑量實(shí)驗(yàn)組尾靜脈注射丙泊酚36,72 mg·kg~(-1)·h~(-1)。術(shù)后28 d,比較4組大鼠術(shù)后的死亡率,用平衡測(cè)驗(yàn)方法檢測(cè)平衡能力,用巴恩斯迷宮法檢測(cè)學(xué)習(xí)記憶能力,用免疫組化法檢測(cè)神經(jīng)元新生狀況。結(jié)果術(shù)后28 d,低高2個(gè)劑量實(shí)驗(yàn)組大鼠死亡率分別為30%,40%,與模型組比較差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。高劑量實(shí)驗(yàn)組大鼠進(jìn)入目的箱時(shí)間為(169.64±6.77)s,顯著高于模型組的(144.21±8.52)s,差異有統(tǒng)計(jì)學(xué)意義(P0.05);高劑量實(shí)驗(yàn)組平衡能力為(37.29±4.26)s,顯著低于模型組的(49.37±5.17)s,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。模型組大鼠的神經(jīng)元新生數(shù)為(680.46±65.17)個(gè),低高2個(gè)劑量實(shí)驗(yàn)組大鼠分別為(364.59±76.21),(302.14±42.77)個(gè),與模型組比較差異均有統(tǒng)計(jì)學(xué)意義(均P0.01)。結(jié)論丙泊酚可降低創(chuàng)傷性腦損傷大鼠神經(jīng)元再生,且對(duì)創(chuàng)傷性腦損傷大鼠具有惡化作用。
[Abstract]:Objective to observe the effect of propofol anesthesia on TBI in rats with traumatic brain injury. Methods TBI model was established by Feeney method. Male Wistar rats were divided into 4 groups according to their body weight: sham operation group, model group and low and high dose groups, 20 rats in each group. Two doses of propofol were injected into caudal vein of the two experimental groups with propofol 72 mg / kg 路kg ~ (-1) 路h ~ (-1) 路L ~ (-1) 路h ~ (-1). On the 28th day after operation, the mortality rate of the four groups was compared. Balance test was used to test the balance ability, Barnes maze method was used to detect the ability of learning and memory, and immunohistochemical method was used to detect the status of neuronal regeneration. Results on the 28th day after operation, the mortality of the rats in the experimental group with low dose and high dose was 30 and 40, respectively, which was significantly different from that of the model group (all P 0.05). The time of entering the box in the high dose group was 169.64 鹵6.77 s, which was significantly higher than that in the model group (144.21 鹵8.52 s, P 0.05), and the balance ability of the high dose group was 37.29 鹵4.26 seconds, which was significantly lower than that in the model group (49.37 鹵5.17 s). The number of neurons in the model group was 680.46 鹵65.17, and that in the low and high dose groups was 364.59 鹵76.21, 302.14 鹵42.77, respectively, which was significantly different from that in the model group (P 0.01). Conclusion propofol can decrease the neuronal regeneration in rats with traumatic brain injury and has a worsening effect on traumatic brain injury.
【作者單位】： 海南醫(yī)學(xué)院第二附屬醫(yī)院麻醉科;新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院腫瘤研究所;海南醫(yī)學(xué)院第二附屬醫(yī)院神經(jīng)外科;
【基金】：海南省自然科學(xué)基金面上基金資助項(xiàng)目(20168296)
【分類(lèi)號(hào)】：R965

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