本文選題：因不良反應(yīng)住院 + 內(nèi)分泌��； 參考：《中國藥學(xué)雜志》2015年12期

【摘要】：目的通過主動監(jiān)測的方式獲取我院內(nèi)分泌病區(qū)因藥物不良反應(yīng)(ADR)入院的發(fā)生率及主要特征,為臨床安全用藥提供參考。方法臨床藥師通過床旁問診方式采集內(nèi)分泌病區(qū)2011年1月至2013年12月因藥物不良反應(yīng)入院患者的詳細資料,并對藥物不良反應(yīng)類型、臨床表現(xiàn)、懷疑藥物、過敏史、住院時間、住院費用以及轉(zhuǎn)歸情況進行分析。結(jié)果 6 914例入院患者中共有40例因藥物不良反應(yīng)入院,占0.58%,男性13例,女性27例,平均年齡(54.82±15.85)歲,平均住院費用(10622.86±6 719.48)元,住院天數(shù)(12.85±7.57)d,其中A型藥物不良反應(yīng)有34例(85.0%),B型藥物不良反應(yīng)有6例(15.0%)。40例藥物不良反應(yīng)共11種藥物不良反應(yīng)表現(xiàn)類型,涉及懷疑藥物27種,主要的藥物不良反應(yīng)表現(xiàn)有低血糖、腎小管損害繼發(fā)低磷軟骨,類固醇糖尿病,粒細胞缺乏(減少)、胰島素過敏、低血鉀,肝酶升高,胰島素自身免疫綜合癥,電解質(zhì)紊亂,甲亢以及甲減,涉及的懷疑藥物主要有胰島素、口服降糖藥物,降糖中成藥(保健品)、甲巰咪唑、阿德福韋酯、腎上腺皮質(zhì)激素等。結(jié)論內(nèi)分泌病區(qū)因藥物不良反應(yīng)住院的比例0.58%,但引起藥物不良反應(yīng)的多為內(nèi)分泌的常用藥物,藥物不良反應(yīng)表現(xiàn)如低血糖、低血鉀、電解質(zhì)紊亂等與內(nèi)分泌系統(tǒng)疾病臨床表現(xiàn)相似,常常會影響診斷,延誤治療,因此在診療過程中,應(yīng)重視藥物的藥物不良反應(yīng)因素。
[Abstract]:Objective to obtain the incidence and main characteristics of ADR in endocrine ward of our hospital by active monitoring, so as to provide reference for safe drug use in clinic. Methods from January 2011 to December 2013, the clinical pharmacists collected the detailed data of patients admitted to the endocrine ward for adverse drug reactions from January 2011 to December 2013, and analyzed the types of adverse drug reactions, clinical manifestations, suspected drugs, history of allergies, and length of stay. Hospital expenses and outcomes were analyzed. Results A total of 40 patients (0.58%) were admitted to hospital because of adverse drug reactions. There were 13 males and 27 females, with an average age of 54.82 鹵15.85 years and an average hospitalization cost of 10622.86 鹵6719.48 yuan. The number of days in hospital was 12.85 鹵7.57 days, of which 34 cases of type A drug adverse reactions (ADRs) were 85.0% (6 / 40). There were 11 types of adverse drug reactions (ADRs) involving 27 suspected drugs. The main adverse drug reactions were hypoglycemia. Renal tubular damage secondary to hypophosphorous cartilage, steroid diabetes, granulocyte deficiency, insulin allergy, hypokalemia, liver enzyme elevation, insulin autoimmune syndrome, electrolyte disorders, hyperthyroidism, and hypothyroidism, The main suspected drugs involved include insulin, oral hypoglycemic drugs, hypoglycemic traditional Chinese medicine (health care products, methimazole, adefovir, adrenal corticosteroids, etc. Conclusion the proportion of patients hospitalized with adverse drug reactions in endocrine areas is 0.58, but the adverse drug reactions are mostly common endocrine drugs, such as hypoglycemia, hypokalemia, hypoglycemia and hypokalemia. Electrolyte disorders are similar to the clinical manifestations of endocrine system diseases, which often affect diagnosis and delay treatment. Therefore, in the course of diagnosis and treatment, attention should be paid to the adverse drug reaction factors.
【作者單位】： 解放軍總醫(yī)院藥品保障中心;解放軍總醫(yī)院內(nèi)分泌科;
【基金】：解放軍總醫(yī)院科技創(chuàng)新苗圃基金資助項目(13KMM46)
【分類號】：R969.3

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