本文選題：依巴斯汀 + 滴丸��； 參考：《中國醫(yī)藥工業(yè)雜志》2017年08期

【摘要】：用熔融法制備依巴斯汀滴丸,利用Box-Behnken響應(yīng)面法優(yōu)化滴丸劑處方與制備工藝,并對預(yù)測結(jié)果進(jìn)行驗(yàn)證。結(jié)果表明所得模型預(yù)測性較好,優(yōu)化處方工藝為:藥物與基質(zhì)的比例為1∶3.4、基質(zhì)中聚乙二醇(PEG)4000∶PEG6000的比例為1∶0.41、熔融溫度為84℃。采用X射線粉末衍射法(XRD)及差示掃描量熱法(DSC)對優(yōu)化滴丸劑表征,并以市售片劑為對照考察自制滴丸的溶出性能。結(jié)果表明,優(yōu)化后所制得的滴丸劑中藥物以非晶態(tài)存在;5~30 min滴丸的溶出速度明顯高于市售片劑,且滴丸的60 min溶出率為(89.0±4.8)%,片劑則為(78.0±4.7)%。
[Abstract]:Ebastine dropping pills were prepared by melting method. The formulation and preparation process of Ebastine dropping pills were optimized by Box-Behnken response surface method, and the predicted results were verified. The results showed that the prediction of the model was good. The optimized formulation process was as follows: the ratio of drug to matrix was 1: 3.4, the proportion of PEGN 4 000 to PEG6000 in the matrix was 1: 0.41, and the melting temperature was 84 鈩，

本文編號：1910838