本文選題：高效液相色譜-串聯(lián)質(zhì)譜 + 硫酸氫氯吡格雷��； 參考：《中國(guó)醫(yī)院藥學(xué)雜志》2017年21期

【摘要】：目的:探究腸道菌群變化對(duì)硫酸氫氯吡格雷及其活性代謝產(chǎn)物在大鼠體內(nèi)藥動(dòng)學(xué)的影響。方法:24只健康大鼠隨機(jī)分為益生菌組、抗生素組和對(duì)照組,每組8只,分別灌胃雙歧桿菌乳桿菌三聯(lián)活菌(0.8 g·kg~(-1))、阿莫西林克拉維酸鉀片(125mg·kg~(-1))和等體積的純化水,連續(xù)7 d。第8天給予硫酸氫氯吡格雷片,并于給藥前和給藥后不同時(shí)間點(diǎn)取血于含有衍生試劑的抗凝管中,LC-MS/MS法測(cè)定血藥濃度,繪制藥時(shí)曲線,使用DAS 2.1.1擬合藥動(dòng)學(xué)參數(shù),SPSS 21.0進(jìn)行統(tǒng)計(jì)學(xué)比較。結(jié)果:益生菌組、抗生素組和對(duì)照組硫酸氫氯吡格雷和活性代謝產(chǎn)物衍生物(CAMD)的主要藥動(dòng)學(xué)參數(shù)AUC_(0-t)、AUC_(0-∞)、t_(1/2)、t_(max)、CL、V、C_(max)均沒(méi)有統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:腸道菌群變化對(duì)硫酸氫氯吡格雷及其活性代謝產(chǎn)物的藥動(dòng)學(xué)參數(shù)沒(méi)有影響。
[Abstract]:Aim: to investigate the effects of intestinal flora changes on the pharmacokinetics of clopidogrel sulfate and its active metabolites in rats. Methods Twenty four healthy rats were randomly divided into three groups: probiotic group, antibiotic group and control group (8 rats in each group). On the 8th day, clopidogrel sulfate tablets were given, and blood samples were collected at different time points before and after administration to determine the concentration of the drug in the anticoagulant tube containing derivative reagent by LC-MS / MS, and to draw the time curve of the drug. The pharmacokinetic parameters of DAS 2.1.1 were statistically compared with that of SPSS 21.0. Results: the main pharmacokinetic parameters of probiotics group, antibiotic group and control group were clopidogrel sulfate and active metabolite derivative CAMD.There was no significant difference in the main pharmacokinetic parameters AUC0 ~ (0)-鈭，

本文編號(hào)：1902152