本文選題：興奮性氨基酸 + 興奮性氨基酸受體��； 參考：《中國藥房》2015年28期

【摘要】：目的:綜述興奮性氨基酸(EAA)、興奮性氨基酸受體(EAARs)及興奮性氨基酸轉(zhuǎn)運體(EAATs)在抗癲癇藥理研究中的意義。方法:以"Excitatory amino acids""Receptor""Transporter""Epilepsy"等為關(guān)鍵詞,在Pub Med數(shù)據(jù)庫中檢索2004-2014年的相關(guān)文獻,歸納總結(jié)后,從EAA、EAARs、EAATs與癲癇發(fā)生發(fā)展的關(guān)系以及在抗癲癇藥理研究中的意義進行綜述。結(jié)果與結(jié)論:檢索到相關(guān)文獻150余條,其中有效文獻40條。中樞神經(jīng)系統(tǒng)EAA水平異常升高、EAATs低表達都可導致谷氨酸(Glu)含量增加,從而誘發(fā)癲癇;EAARs因受到不適當刺激而產(chǎn)生興奮毒性,導致神經(jīng)元細胞損傷或缺失也是癲癇發(fā)作原因之一。EAA和代謝型Glu受體(m Glu Rs)可能對癲癇的治療提供新的思路并為研制理想治療藥物提供了有益的靶標。作用于m Glu Rs和EAATs的藥物、調(diào)節(jié)第二類m Glu Rs和EAATs的基因或影響相應(yīng)蛋白表達的藥物應(yīng)用于臨床,將對癲癇的防治發(fā)揮積極作用。
[Abstract]:Aim: to review the significance of excitatory amino acid receptor (EAARs) and excitatory amino acid transporter (EAATs) in antiepileptic pharmacological studies. Methods: using "Excitatory amino acids" Receptor "," Transporter "Epilepsy" as the key words, the relevant literatures from 2004 to 2014 were searched in the Pub Med database. The relationship between EAA, EAARs, EAATs and the occurrence and development of epilepsy and its significance in the study of antiepileptic pharmacology were summarized. Results & conclusion: more than 150 articles were retrieved, 40 of which were valid. The abnormal elevation of EAA level in central nervous system and the low expression of EAATs can lead to the increase of glutamate Glu-content, which may induce excitotoxicity of epileptic seizures induced by inappropriate stimulation. EAA and metabotropic Glu receptor m Glu Rsmay provide new ideas for the treatment of epilepsy and provide a useful target for the development of ideal therapeutic drugs. Drugs acting on m Glu Rs and EAATs, regulating the genes of m Glu Rs and EAATs or affecting the expression of corresponding proteins, will play an active role in the prevention and treatment of epilepsy.
【作者單位】： 重慶市黔江中心醫(yī)院藥學部;
【分類號】：R966

【共引文獻】

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本文編號：1866232