本文選題：阿司匹林 + 磷脂復(fù)合物��； 參考：《中國(guó)藥房》2017年25期

【摘要】：目的:制備阿司匹林磷脂復(fù)合物(ASP-PC)并進(jìn)行表征。方法:以ASP與PC的復(fù)合率為指標(biāo),采用單因素試驗(yàn)篩選ASP-PC的制備方法、PC種類、溶劑種類、反應(yīng)時(shí)間、反應(yīng)溫度、溶劑體積和藥脂比,并進(jìn)行驗(yàn)證。采用紫外分光光度法、熱重分析法、X射線衍射法和傅里葉紅外光譜分析對(duì)所制ASP-PC進(jìn)行表征。結(jié)果:采用磁力攪拌-冷凝回流法,藥物-大豆磷脂比為1∶3(mol/mol),溶劑為四氫呋喃(50 m L),58℃下反應(yīng)3 h,所制ASP-PC的平均復(fù)合率為83.52%(RSD=1.16%,n=3)。與ASP、ASP和PC的物理混合物比較,紫外光譜顯示ASP-PC沒有出現(xiàn)新的吸收峰;熱重分析、X射線衍射分析和傅里葉紅外光譜分析顯示ASP-PC中的ASP與PC發(fā)生了相互作用,且ASP-PC在0~300℃范圍內(nèi)質(zhì)量變化較小。結(jié)論:成功制得ASP-PC,其中ASP與PC復(fù)合成功,但仍有微量ASP以晶體形式存在。
[Abstract]:Objective: to prepare and characterize aspirin phospholipid complex (ASP-PCC). Methods: single factor test was used to select the preparation method of ASP and PC, such as the type of PC, the kind of solvent, the reaction time, the reaction temperature, the volume of solvent and the ratio of drug to lipid. The ASP-PC was characterized by ultraviolet spectrophotometry, thermogravimetric analysis, X-ray diffraction and Fourier transform infrared spectroscopy. Results: by magnetic agitation-condensation reflux method, the ratio of drug to soybean phospholipid was 1: 3 mol / L, and the solvent was tetrahydrofuran 50 mL / L for 3 h. The average compound rate of ASP-PC was 83.52%. Compared with the physical mixture of ASP-PC and PC, UV spectra showed no new absorption peaks in ASP-PC, and thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) showed that ASP in ASP-PC interacted with PC. The mass change of ASP-PC is small in the range of 0 ~ 300 鈩，

本文編號(hào)：1854420