發(fā)布時間：2018-05-06 01:10

  本文選題：伏立康唑 + 藥品不良反應�。� 參考：《中國藥房》2015年17期

【摘要】：目的:了解我院應用伏立康唑所致藥品不良反應(ADR)發(fā)生的特點及一般規(guī)律,為臨床合理用藥提供參考。方法:通過廣東省ADR管理平臺,在ADR報表統(tǒng)計模塊中,以通用名稱"伏立康唑"對我院2007-2014年的數(shù)據(jù)進行檢索,導出Excel報表。對伏立康唑致ADR患者的性別、年齡、用藥方案(包括給藥劑量、途徑和天數(shù))、ADR名稱、臨床表現(xiàn)和處理等進行統(tǒng)計、分析。結(jié)果:所收集的30例伏立康唑所致ADR報告中,ADR以消化系統(tǒng)、精神與行為障礙、神經(jīng)系統(tǒng)和眼睛及其附屬器官等損害為主,占77.78%;20例ADR為靜脈滴注給藥;30例ADR平均發(fā)生時間為4.65 d,其中≤1 d發(fā)生的有11例;所有的ADR均治愈,無遺留后遺癥或死亡。結(jié)論:臨床應用伏立康唑時,應注意觀察ADR的發(fā)生,尤其是聯(lián)用與伏立康唑有相互作用的藥物時,更要注意藥物劑量調(diào)整和ADR監(jiān)測。有條件時可進行伏立康唑的血藥濃度監(jiān)測,確保用藥安全。
[Abstract]:Objective: to understand the characteristics and general rules of ADR induced by Volconazole in our hospital, and to provide reference for rational drug use in clinic. Methods: the data of our hospital from 2007 to 2014 were retrieved by using the general name "Voliconazole" in the ADR report statistical module of Guangdong Province ADR management platform, and the Excel report form was derived. The sex, age, drug regimen (including dosage, route and days of administration), clinical manifestation and treatment of ADR patients induced by Volconazole were analyzed and analyzed. Results: in 30 cases of ADR induced by Volconazole, digestive system, mental and behavioral disorders, nervous system, eyes and accessory organs were the main types of ADRs. The average time of occurrence of ADR was 4.65 days in 30 patients with ADR and 20 cases with ADR, of which 11 cases occurred less than 1 day. All ADR cases were cured without any sequelae or death. Conclusion: it is necessary to observe the occurrence of ADR in clinical application of Veconazole, especially when combined with Volconazole, the dosage adjustment and ADR monitoring should be paid more attention to. In order to ensure the safety of drug use, the plasma concentration of volconazole can be monitored when conditions are available.
【作者單位】： 深圳市第二人民醫(yī)院藥學部臨床藥學科;深圳市眼科醫(yī)院藥劑科;
【基金】：深圳市科技計劃項目(No.JCYJ20140414170821258)
【分類號】：R969.3

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本文編號：1850099