本文選題：門診 + 奧美拉唑　； 參考：《中國藥房》2017年35期

【摘要】：目的:調(diào)查門診奧美拉唑超說明書用藥情況,為臨床合理用藥提供參考。方法:采用回顧性調(diào)查的方法,并用隨機數(shù)字表法抽取某院門診2014年6月-2017年5月使用奧美拉唑的處方1 838張,根據(jù)最新版藥品說明書,判斷是否超說明書用藥;通過查閱國內(nèi)外指南、文獻和Micromedex數(shù)據(jù)庫等對超說明書用藥進行分析。結(jié)果:1 838張?zhí)幏街?超說明書用藥處方有1 750張(95.21%),涉及3種類型、13項超說明書用藥內(nèi)容。超說明書用藥類型主要為超適應(yīng)證用藥,共1 747張(96.47%)。消化內(nèi)科和非消化內(nèi)科超說明書用藥發(fā)生率、不同級別醫(yī)師超說明書用藥發(fā)生率比較,差異均無統(tǒng)計學意義(P0.05)。13項超說明書用藥內(nèi)容中,7項有國內(nèi)外指南、專家共識/建議或文獻報道等不同級別的循證醫(yī)學證據(jù)支持,但其中僅有1項被Micromedex的Thomson分級系統(tǒng)收錄,其余6項均無任何循證醫(yī)學證據(jù)。結(jié)論:該院門診奧美拉唑超說明書用藥現(xiàn)象普遍,部分超說明書用藥有證據(jù)支持,但各證據(jù)質(zhì)量存在差異。臨床應(yīng)規(guī)范說明書應(yīng)用以避免法律風險,確�；颊甙踩盟帯�
[Abstract]:Objective: to investigate the drug usage of Omeprazole superscript in outpatient clinic and to provide reference for rational use of Omeprazole in clinic. Methods: 1 838 Omeprazole prescriptions were collected from outpatients of a hospital from June 2014 to May 2017 by retrospective investigation and random digital table method. According to the latest version of drug instructions, whether the prescriptions were over-prescribed or not was judged. By consulting the domestic and foreign guidelines, literature and Micromedex database to analyze the hypermanual drug use. Results among the 1 838 prescriptions, there were 1 750 prescriptions in the overstatement, involving 13 items in 3 kinds of prescriptions. The main types of drug use in superscript were super indications, a total of 1 747 pieces of drug. There were no significant differences in the incidence of over-instruction drug use between internal medicine department and non-digestive internal medicine department, and there were no significant differences in the incidence rate of over-instruction drug use among doctors of different grades. There were no statistical significance in 7 of the 13 items of hyperinstruction drug use content, which had domestic and foreign guidelines. The expert consensus / recommendation or literature reports supported the evidence of evidence-based medicine at different levels, but only one of them was included in Micromedex's Thomson classification system, and the other 6 items were not supported by any evidence of evidence-based medicine. Conclusion: Omeprazole superscript drug use is common in outpatient department of our hospital, some of them are supported by evidence, but the quality of evidence is different. Clinical specifications should be standardized to avoid legal risks and ensure safe use of drugs for patients.
【作者單位】： 廣州中醫(yī)藥大學附屬廣東中西醫(yī)結(jié)合醫(yī)院;廣東省中西醫(yī)結(jié)合醫(yī)院藥學部;廣東省中西醫(yī)結(jié)合醫(yī)院消化內(nèi)科;
【基金】：廣東省醫(yī)院藥學研究基金項目(No.2016A22)
【分類號】：R975

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