本文選題：果膠 + 結(jié)腸給藥系統(tǒng)�。� 參考：《中國醫(yī)藥工業(yè)雜志》2017年09期

【摘要】：探討殼聚糖和卵磷脂對果膠凝膠球的改性作用,以酮洛芬(KTP)為藥物模型,對比不同交聯(lián)劑(Ca~(2+)和Zn~(2+))形成的果膠-殼聚糖-卵磷脂復(fù)合凝膠球的性能。通過改變處方的殼聚糖濃度、卵磷脂濃度、交聯(lián)劑p H值等進(jìn)行單因素試驗(yàn),考察各因素對凝膠球粒徑、粒重、載藥量、包封率和體外釋藥的影響。結(jié)果表明,殼聚糖的加入對鈣體系和鋅體系的凝膠球載藥量影響不大;隨著卵磷脂的加入,2種凝膠球的載藥量都呈現(xiàn)降低趨勢;2種凝膠球的包封率都在一定范圍內(nèi)隨著殼聚糖和卵磷脂濃度的增加而升高。載KTP的鈣體系果膠-殼聚糖-卵磷脂復(fù)合凝膠球在模擬小腸(SIF)階段釋藥90%以上,達(dá)不到結(jié)腸給藥的目的 ;鋅體系果膠-殼聚糖-卵磷脂復(fù)合凝膠球在SIF階段釋藥10%,在模擬結(jié)腸液(SCF)階段釋藥83.21%,提示殼聚糖、卵磷脂共同改性的果膠鋅凝膠球有一定的結(jié)腸給藥效果。
[Abstract]:The effects of chitosan and lecithin on the modification of pectin gel spheres were studied. Using ketoprofen KTPas as drug model, the properties of pectin chitosan lecithin composite gel spheres formed by different crosslinking agents (Zn~(2) and different crosslinkers were compared. By changing the concentration of chitosan, the concentration of lecithin and the value of crosslinking agent pH, the effects of various factors on the particle size, particle weight, drug loading, encapsulation efficiency and drug release in vitro were investigated. The results showed that the addition of chitosan had little effect on the amount of gels loaded in calcium and zinc systems. With the addition of lecithin, the drug loading of the two kinds of gels showed a decreasing trend. The entrapment efficiency of the two kinds of gels increased with the increase of chitosan and lecithin concentration in a certain range. Pectin-chitosan-lecithin composite gel spheres loaded with KTP released more than 90% of the drugs in the simulated small intestinal sif stage, which could not achieve the purpose of colonic administration. In zinc system, Pectin / chitosan / lecithin composite gel spheres released 10 drugs at SIF stage and 83.21 at simulated colonic fluid stage, suggesting that chitosan and lecithin modified Pectin zinc gel spheres have a certain colonic drug delivery effect.
【作者單位】： 天津科技大學(xué)化工與材料學(xué)院;
【分類號】：R943
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本文編號：1826823