本文選題：干粉吸入劑 + 載體　； 參考：《藥學(xué)學(xué)報(bào)》2017年09期

【摘要】：本研究制備了一種新型的干粉吸入劑載體,并用于噻托溴銨的吸附和脫附應(yīng)用。合成的藥用花形載體乳糖微粒呈結(jié)晶態(tài),含微-介-大孔均勻分布的孔結(jié)構(gòu),且具有高孔隙率、高載藥量和高藥物釋放效率的優(yōu)點(diǎn)。在噻托溴銨吸附研究中,采用溶液吸附法結(jié)合的噻托溴銨分子集中分布在花形微粒的內(nèi)部,載體形貌變化小,測得的藥物吸附量為5%(w/w,固體質(zhì)量比),而采用結(jié)晶吸附法結(jié)合的噻托溴銨分子集中分布在花形微粒的外部,載體形貌變化大,測得的藥物吸附量為49%(w/w)。此外,在載體的幾何形貌影響下,采用溶液吸附法制備的制劑,其藥物釋放速率先快后慢;而采用結(jié)晶吸附法制備的制劑,其藥物釋放速率先慢后快。因此,該乳糖微粒可作為一種新型的藥用載體,用于干粉吸入劑。
[Abstract]:In this study, a new dry powder absorbent carrier was prepared and used for the adsorption and desorption of thiotropium bromide. The synthesized drug flower carrier lactose particles are crystalline, with micromeso-macroporous pore structure, and have the advantages of high porosity, high drug loading and high drug release efficiency. In the study of thiotropium bromide adsorption, the tiotropium bromide molecules combined with the solution adsorption method were concentrated inside the floral particles, and the morphology of the carrier changed little. The drug adsorption capacity was measured to be 5w / w, and the solid mass ratio was obtained. However, the tiotropium bromide molecules combined with crystal adsorption method were concentrated on the outside of the flower-shaped particles, and the morphology of the carrier changed greatly. The drug adsorption capacity measured was 49w / w / w ~ (-1). In addition, under the influence of the geometric morphology of the carrier, the drug release rate of the preparation prepared by solution adsorption method was first fast and then slow, while the drug release rate of the preparation prepared by crystal adsorption method was first slow and then fast. Therefore, the lactose particles can be used as a new drug carrier for dry powder inhalation.
【作者單位】： 澳高科公司;長沙方圓咨詢有限公司;韓國高麗大學(xué)生物醫(yī)藥工程系;澳大利亞悉尼科技大學(xué)工程學(xué)院;
【基金】：澳高科公司企業(yè)資助項(xiàng)目(Auhightech 2017001)
【分類號(hào)】：R943

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本文編號(hào)：1818545