本文選題：固體分散體 + 溶出度��； 參考：《中國醫(yī)院藥學(xué)雜志》2015年02期

【摘要】：目的:采用固體分散體技術(shù)考察不同載體材料對布渣葉總黃酮提取物溶出度的影響。方法:選擇不同種類的聚乙二醇、泊洛沙姆、聚乙烯吡咯烷酮為載體材料,與布渣葉總黃酮提取物按質(zhì)量比1∶4混合均勻,分別用熔融法和溶劑法制備固體分散體,以固體分散體中總黃酮、牡荊苷、異牡荊苷、水仙苷的90 min累積溶出度作為評價(jià)指標(biāo),比較不同載體制備的固體分散體的釋藥速率,并采用X射線衍射和紅外光譜分析對其物相特征進(jìn)行研究。結(jié)果:與布渣葉總黃酮提取物和物理混合物相比,以PEG和泊洛沙姆所制備的布渣葉提取物固體分散體中總黃酮、牡荊苷、異牡荊苷和水仙苷的體外溶出度與溶出速率均明顯增加。其中以泊洛沙姆407為載體材料所制備的固體分散體中總黃酮體外溶出度最佳,90 min累積溶出度達(dá)到84%;以PEG6000為載體材料所制備的固體分散體中牡荊苷、異牡荊苷、水仙苷體外溶出度最佳,90 min累積溶出度均達(dá)96%以上。結(jié)論:采用固體分散體技術(shù),選擇PEG6000或泊洛沙姆407為載體制備布渣葉總黃酮提取物固體分散體,對提取物中脂溶性成分的溶出有明顯改善作用。
[Abstract]:Objective: to investigate the effect of different carrier materials on the dissolution of total flavonoids extract from leaves of cloth dregs by solid dispersion technique. Methods: different kinds of polyethylene glycol, Poloxamer and polyvinylpyrrolidone were selected as carrier materials. The solid dispersions were prepared by melting method and solvent method, respectively. The cumulative dissolution of total flavonoids, peucosides, isopynosides and narcissus in solid dispersions at 90 min was used as the evaluation index to compare the drug release rates of solid dispersions prepared with different carriers. The phase characteristics were studied by X-ray diffraction and infrared spectroscopy. Results: compared with the total flavonoids extract and the physical mixture, the total flavonoids and vitexin in the solid dispersion of the extract from the leaves of cloth dregs were prepared by PEG and Poloxamer. The dissolution rate and dissolution rate of isopodioside and narcissus increased significantly in vitro. The dissolution of total flavonoids in solid dispersion prepared by Poloxamer 407 was the best in vitro, and the cumulative dissolution of total flavonoids in 90 min was 84%, while that in solid dispersion prepared with PEG6000 as carrier material was as high as 84%. The best dissolution of narcissus in vitro was above 96% for 90 min. Conclusion: PEG6000 or Poloxamer 407 were selected as carriers to prepare solid dispersion of total flavonoids extract from leaves of cloth dregs by solid dispersion technique, which can improve the dissolution of liposoluble components in the extracts.
【作者單位】： 廣東省中醫(yī)研究所;廣州中醫(yī)藥大學(xué);
【基金】：廣東省科技廳重大科技專項(xiàng)(編號:2012A080202016)
【分類號】：R943

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