本文選題：氟康唑 + 立方液晶凝膠　； 參考：《軍事醫(yī)學(xué)》2015年12期

【摘要】：目的對(duì)氟康唑立方液晶凝膠進(jìn)行表征,建立氟康唑含量測(cè)定方法。方法以甘油單油酸酯(GMO)為液晶材料制備氟康唑立方液晶凝膠,偏光顯微鏡及小角X衍射儀(SAXS)對(duì)氟康唑立方液晶凝膠進(jìn)行表征;采用高效液相色譜法測(cè)定立方液晶凝膠中氟康唑的含量。結(jié)果立方液晶凝膠在偏光顯微鏡(PLM)下為暗視野;SAXS顯示空白立方液晶凝膠中出現(xiàn)2個(gè)信號(hào)峰,分別是q1(0.832 09 nm~(-1))和q2(1.017 nm~(-1));氟康唑立方液晶凝膠中出現(xiàn)2個(gè)信號(hào)峰,分別是q1(0.818 88 nm~(-1))和q2(0.950 95 nm~(-1))。高效液相色譜法測(cè)定立方液晶凝膠中氟康唑在20~500μg/ml范圍內(nèi)線性關(guān)系良好。結(jié)論 PLM及SAXS適宜于立方液晶凝膠表征,高效液相測(cè)定方法可用于氟康唑立方液晶凝膠的質(zhì)量控制和評(píng)價(jià)。
[Abstract]:Objective to characterize fluconazole cubic liquid crystal gel and to establish a method for the determination of fluconazole. Methods Fluconazole cubic liquid crystal gel was prepared by using glycerol monooleate (GMOO) as the liquid crystal material. The fluconazole cubic liquid crystal gel was characterized by polarizing light microscope and small angle X-ray diffractometer (SAXS). The content of fluconazole in cubic liquid crystal gel was determined by HPLC. Results there were two signal peaks in the blank cubic liquid crystal gel displayed by dark field SAXS under polarizing microscope (PLM), which were q1O0.83209nmmP-1) and q21.017nmmnm-1, respectively, and two signal peaks appeared in fluconazole cubic liquid crystal gel (Q12.81888nmm-1) and q2O0.950nmm-1 (respectively) and Q2O0.950nmm-1 / 1 (respectively). The results showed that there were two signal peaks in the cubic liquid crystal gel of fluconazole (Q12. 818. 88 nmm-1) and Q2 (0. 995 nmm-1), respectively. The linear range of fluconazole in cubic liquid crystal gel was 20 渭 g/ml. Conclusion PLM and SAXS are suitable for the characterization of cubic liquid crystal gel. The HPLC method can be used for the quality control and evaluation of fluconazole cubic liquid crystal gel.
【作者單位】： 安徽醫(yī)科大學(xué)解放軍307臨床學(xué)院;軍事醫(yī)學(xué)科學(xué)院附屬醫(yī)院藥學(xué)部;
【分類號(hào)】：R927.2;O657.72
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本文編號(hào)：1780400