本文選題：右蘭索拉唑 + 藥動學(xué)��； 參考：《中國醫(yī)院藥學(xué)雜志》2017年14期

【摘要】：目的:研究右蘭索拉唑緩釋膠囊在比格犬體內(nèi)的藥動學(xué)特征。方法:將6只比格犬隨機分為2組,采用雙周期雙交叉給藥方法,單次灌胃60 mg右蘭索拉唑緩釋膠囊受試制劑或參比制劑,LC-MS/MS法測定比格犬體內(nèi)右蘭索拉唑血藥濃度,計算藥動學(xué)參數(shù)并進(jìn)行生物等效性評價。結(jié)果:單次灌胃受試制劑和參比制劑后,比格犬血漿中右蘭索拉唑的t1/2分別為(1.34±0.73)和(1.42±0.63)h,Tmax分別為(5.7±0.52)和(5.8±1.17)h,Cmax分別為(385.5±37.14)和(380.5±53.3)ng·mL~(-1),AUC0-t分別為(1 463.9±213.2)和(1 502.3±147.8)ng·h·mL~(-1),AUC0-∞分別為(1 476.4±215.7)和(1 514.3±149.5)ng·h·mL~(-1)。結(jié)論:右蘭索拉唑緩釋膠囊受試制劑與參比制劑在比格犬體內(nèi)生物等效。
[Abstract]:Objective: to study the pharmacokinetics of desoprazole sustained-release capsules in Beagle dogs.Methods: six Beagle dogs were randomly divided into two groups. The blood concentration of dexlansoprazole was determined by single oral administration of 60 mg dexlansoprazole sustained release capsule or reference preparation (LC-MS / MS).Pharmacokinetic parameters were calculated and bioequivalence was evaluated.緇撴灉:鍗曟鐏岃儍鍙楄瘯鍒跺墏鍜屽弬姣斿埗鍓傚悗,姣旀牸鐘嫻嗕腑鍙沖叞绱㈡媺鍞戠殑t1/2鍒嗗埆涓，

本文編號：1751400