本文選題：萬古霉素　切入點(diǎn)：新生兒　出處：《中國醫(yī)院藥學(xué)雜志》2015年03期

【摘要】：目的:評價萬古霉素在新生兒的臨床應(yīng)用及其血藥濃度監(jiān)測情況,為臨床合理用藥提供參考。方法:采用回顧性分析方法,收集2012-2013年在新生兒使用萬古霉素治療并進(jìn)行血藥濃度監(jiān)測的39例,對其疾病分布、病原學(xué)檢查、PCT檢測、藥物敏感試驗(yàn)、用藥天數(shù)、藥物療效、合并用藥、肝腎功能等指標(biāo)進(jìn)行統(tǒng)計分析。結(jié)果:39例患兒中臨床第一診斷為新生兒肺炎者比例最高,為29例(74.36%);病原學(xué)送檢率100%,陽性檢出率69.2%;藥物敏感試驗(yàn)顯示對萬古霉素高度敏感的占77.78%;PCT送檢率97.44%;萬古霉素血藥谷濃度范圍在15~20μg·ml-1的為19.05%;平均用藥時間(12.4±4.9)d;聯(lián)合應(yīng)用2種抗菌藥物的比例為84.62%;抽樣患兒使用萬古霉素治療的有效率為89.7%。結(jié)論:新生兒使用萬古霉素治療由革蘭陽性菌引起的重癥感染療效確切,但應(yīng)進(jìn)行血藥濃度(谷濃度)監(jiān)測,使其血藥濃度維持在安全有效范圍內(nèi),以提高用藥的安全性和有效性。
[Abstract]:Objective: to evaluate the clinical application of vancomycin in neonates and to provide reference for rational use of vancomycin.Methods: a retrospective analysis was carried out on 39 newborns who were treated with vancomycin and monitored their blood drug concentrations in 2012-2013. The disease distribution, etiological examination, PCT test, drug sensitivity test, drug use days, and drug efficacy were analyzed.Combined use of drugs, liver and kidney function and other indicators for statistical analysis.Results among 39 cases, the proportion of newborns with pneumonia was the highest.涓，

本文編號：1712388