本文選題：甘草酸二銨　切入點：二元脂質(zhì)體　出處：《中成藥》2017年11期

【摘要】：目的制備甘草酸二銨二元脂質(zhì)體溫敏凝膠,并評價其體外釋藥行為。方法冷溶法制備凝膠。以膠凝溫度為評價指標,泊洛沙姆407(P407)、泊洛沙姆188(P188)、白芨多糖用量為影響因素,星點設(shè)計-效應(yīng)面法優(yōu)化處方。再采用HPLC和Franz立式擴散池法評價其體外釋藥行為。結(jié)果最優(yōu)處方為P407用量18%,P188用量4%,多糖用量0.6%,膠凝溫度(37.5±0.3)℃。所得二元脂質(zhì)體溫敏凝膠在48 h內(nèi)的累積釋放率為(65.52±0.63)%,與脂質(zhì)體及溫敏凝膠相比緩釋作用更明顯。結(jié)論甘草酸二銨二元脂質(zhì)體溫敏凝膠可減緩藥物在直腸內(nèi)的釋放速率,并增加其滯留時間。
[Abstract]:Objective to prepare diammonium glycyrrhizinate binary lipid thermo-sensitive gel and evaluate its drug release behavior in vitro.Methods Gel was prepared by cold dissolution method.The gelation temperature was taken as the evaluation index, Poloxamer 407, Poloxamer 188 P188, and the amount of Bletilla striata polysaccharides as the influencing factors, and the star design-effect surface method was used to optimize the formulation.Then HPLC and Franz vertical diffusion cell were used to evaluate the drug release behavior in vitro.Results the optimum prescription was: P407 18: P188 4, polysaccharide 0.610, gelation temperature 37.5 鹵0.3 鈩，

本文編號：1708308