本文選題：姜黃素　切入點(diǎn)：Pickering乳劑　出處：《中草藥》2017年09期

【摘要】：目的使用姜黃素納米晶(curcumin nanocrystalline,Cur-NC)作為固體顆粒穩(wěn)定劑,制備Cur-NC自穩(wěn)定Pickering乳劑(Cur-NC self-stabilized Pickering emulsion,Cur-NCSPE)。方法采用高壓均質(zhì)機(jī)制備Cur-NCSPE;比較不同的均質(zhì)壓力對(duì)Cur-NC粒徑的影響,考察Cur-NC的加入量對(duì)Cur-NCSPE形成的影響,用光學(xué)顯微鏡、掃描電子顯微鏡觀察乳劑的形態(tài)與結(jié)構(gòu),對(duì)Cur-NCSPE的穩(wěn)定性及體外藥物釋放進(jìn)行考察。結(jié)果隨著高壓均質(zhì)壓力的增加,Cur-NC的粒徑逐漸減小,當(dāng)高壓均質(zhì)壓力大于100 MPa后,Cur-NC的粒徑變化趨于平穩(wěn);隨著姜黃素(curcumin,Cur)投入量的增加,Cur-NC對(duì)油滴的包裹量增大,乳滴的粒徑逐漸減小,當(dāng)加入的藥物量能夠?qū)⒂偷瓮耆鼤r(shí),繼續(xù)增大藥物量對(duì)乳滴粒徑的影響不再明顯。Cur-NCSPE的穩(wěn)定性比Cur-NC和Cur高,Cur-NCSPE的體外釋放速率比Cur-NC和Cur的釋放速率顯著加快。結(jié)論成功制備了Cur-NCSPE,有望為中藥難溶性成分提供新的口服給藥技術(shù)平臺(tái)。
[Abstract]:Objective to prepare Cur-NC self-stable Pickering emulsion Cur-NC self-stabilized Pickering emulsionCur-NCSPEE using curcumin nanocrystalline Cur-NCas as solid particle stabilizer.Methods Cur-NCSPEs were prepared by high pressure homogenizer, the effect of different homogenization pressure on the particle size of Cur-NC was compared, the effect of Cur-NC addition on the formation of Cur-NCSPE was investigated, and the morphology and structure of emulsion were observed by optical microscope and scanning electron microscope.The stability of Cur-NCSPE and drug release in vitro were investigated.Results with the increase of high pressure homogenization pressure, the particle size of Cur-NC gradually decreased, when the pressure of high pressure was more than 100 MPa, the particle size of Cur-NC tended to be stable, and with the increase of the amount of curcumin (Curcumin Curn), the amount of oil droplet encapsulated by Cur-NC increased.The size of the emulsion droplets decreases gradually, and when the amount of the added drug is able to completely encapsulate the oil droplets,The stability of Cur-NCSPE was higher than that of Cur-NC and Cur. The release rate of Cur-NCSPE in vitro was significantly faster than that of Cur-NC and Cur.Conclusion Cur-NCSPEhas been successfully prepared, which is expected to provide a new platform for oral administration of insoluble components of traditional Chinese medicine.
【作者單位】： 重慶醫(yī)科大學(xué)藥學(xué)院重慶高校藥物工程研究中心;
【基金】：重慶市自然科學(xué)基金資助項(xiàng)目(cstc2016jcyjA0068)
【分類號(hào)】：R943

【相似文獻(xiàn)】

相關(guān)期刊論文 前7條

1 周君;喬秀穎;孫康;;Pickering乳液的制備和應(yīng)用研究進(jìn)展[J];化學(xué)通報(bào);2012年02期

2 劉登衛(wèi);賀擁軍;郭曉濱;張超;李紫萱;高綺;;基于Pickering乳液介質(zhì)萃取苯胺的研究[J];高校化學(xué)工程學(xué)報(bào);2012年03期

3 張衛(wèi)紅;范曉東;王景霞;田威;;Pickering乳液聚合技術(shù)在制備中空復(fù)合體中的應(yīng)用[J];現(xiàn)代化工;2008年11期

4 鄒聲文;王朝陽(yáng);魏增江;劉浩;童真;;粒子與聚合物協(xié)同穩(wěn)定高內(nèi)相Pickering乳液[J];化學(xué)學(xué)報(bào);2012年02期

5 田鵬飛;劉溫霞;;Pickering石蠟乳狀液的研制[J];造紙化學(xué)品;2008年05期

6 顏慧瓊;李嘉誠(chéng);馮玉紅;胡文濤;劉若林;林強(qiáng);;改性海藻酸鈉活化SiO_2納米粒子穩(wěn)定載藥Pickering乳液及釋藥性[J];高等學(xué)�；瘜W(xué)學(xué)報(bào);2013年09期

7 ;[J];;年期

相關(guān)會(huì)議論文 前2條

1 于得海;劉溫霞;;Pickering 乳狀液穩(wěn)定理論及其在造紙中的應(yīng)用價(jià)值[A];’2008（第十六屆）全國(guó)造紙化學(xué)品開(kāi)發(fā)應(yīng)用技術(shù)研討會(huì)論文集[C];2008年

2 楊宇;王朝陽(yáng);童真;;Pickering高內(nèi)相乳液模板法制備多孔泡沫[A];2013年全國(guó)高分子學(xué)術(shù)論文報(bào)告會(huì)論文摘要集——主題F：功能高分子[C];2013年

相關(guān)博士學(xué)位論文 前1條

1 殷冠南;基于Pickering乳液聚合的功能性聚合物微球制備及機(jī)理研究[D];復(fù)旦大學(xué);2013年

相關(guān)碩士學(xué)位論文 前1條

1 劉若林;改性海藻酸鈉與LDH納米顆粒協(xié)同穩(wěn)定載藥Pickering乳液緩釋研究[D];海南大學(xué);2014年

，

本文編號(hào)：1708161