本文選題：甲氧芐啶　切入點(diǎn)：磺丁基醚-β-環(huán)糊精　出處：《中國藥學(xué)雜志》2017年13期

【摘要】：目的制備甲氧芐啶-磺丁基醚-β-環(huán)糊精包合物,并對其進(jìn)行條件優(yōu)化、表征和分子模擬。方法采用超聲微波-冷凍干燥法制備包合物,使用Box-Behnken響應(yīng)面法進(jìn)行條件優(yōu)化;采用紅外光譜法(FT-IR)、差示掃描量熱法(DSC)、粉末X衍射法(XRPD)及核磁共振法(~1H-NMR)對包合物進(jìn)行表征;采用分子對接技術(shù),模擬包合物的三維構(gòu)象及結(jié)合能;進(jìn)行溶出度和穩(wěn)定性實(shí)驗。結(jié)果甲氧芐啶-磺丁基醚-β-環(huán)糊精包合物的最佳制備工藝為包合溫度為52℃,包合時間為45 min,投料摩爾比為1.7∶1;紅外光譜、差示掃描量熱圖譜、粉末X衍射圖譜和核磁共振圖譜均表明TMP/SBE7-β-CD包合物形成;分子模擬的包合物最優(yōu)構(gòu)象與表征分析相符,包合物結(jié)合能為-9.015 kcal·mol~(-1);包合物的TMP溶出速率明顯增加,但包合物易吸濕。結(jié)論甲氧芐啶-磺丁基醚-β-環(huán)糊精包合物制備工藝合理可行,表征方法系統(tǒng)可靠,包合物相對穩(wěn)定。
[Abstract]:Objective to prepare the inclusion compound of trimethoprim sulfosulfonate Ding Ji ether- 尾 -cyclodextrin and optimize its condition, characterization and molecular simulation. Methods the inclusion compound was prepared by ultrasonic microwave freeze drying method and optimized by Box-Behnken response surface method. The inclusion complexes were characterized by FT-IR, DSC, XRPDand 1H-NMR.The molecular docking technique was used to simulate the three-dimensional conformation and binding energy of the inclusion complexes. Results the optimum preparation process of trimethoprim sulfo#china_person0# ether- 尾 -cyclodextrin inclusion complex was as follows: inclusion temperature 52 鈩，

本文編號：1684420