本文選題：尿液　切入點：生物分析　出處：《中國新藥雜志》2017年08期 　論文類型：期刊論文

【摘要】：尿液樣本中藥物濃度的分析測定是新藥開發(fā)的重要環(huán)節(jié)。由于尿液樣本與全血、血漿和血清等含有蛋白質(zhì)和脂質(zhì)的生物樣本間成分的差異,在檢測尿樣中的藥物濃度時可能會存在非特異性吸附的問題。本文對尿樣非特異性吸附問題的驗證和解決方法進行概述,并對其中需要關注的問題進行探討,旨在對廣大生物樣本分析的研究者提供借鑒。
[Abstract]:Analysis and determination of drug concentration in urine samples is an important step in the development of new drugs. Because of the differences between urine samples and biological samples containing proteins and lipids, such as whole blood, plasma and serum, The problem of nonspecific adsorption may exist in the determination of drug concentration in urine samples. In this paper, the verification and solution of nonspecific adsorption problems in urine samples are summarized, and the problems that need to be paid attention to are discussed. The purpose of this study is to provide a reference for researchers in the analysis of a wide range of biological samples.
【作者單位】： 中國人民解放軍成都軍區(qū)總醫(yī)院臨床藥學科;
【分類號】：R969

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1 張賢安;抗蛋白質(zhì)非特異性吸附納米磁球的制備及其在免疫檢測中的應用[D];浙江大學;2011年

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本文編號：1644604