本文選題：姜黃素　切入點(diǎn)：納米混懸劑　出處：《遼寧中醫(yī)藥大學(xué)學(xué)報(bào)》2016年12期 　論文類型：期刊論文

【摘要】：目的:制備姜黃素納米混懸劑,并研究其體外溶出度。方法:采用高壓均質(zhì)法制備姜黃素納米混懸劑,以納米混懸劑粒徑分布、Pd I和Zeta電位為指標(biāo),考察了姜黃素納米混懸劑的影響因素,對(duì)制得的納米混懸劑進(jìn)行表征,并比較姜黃素納米混懸劑溶液、固化納米混懸劑和原料藥的溶出速率和溶出量。結(jié)果:姜黃素納米混懸劑平均粒徑為(396.4±67.2)nm,Pd I為(0.369±0.061),Zeta電位為(-16.7±3.5)m V;掃描電鏡顯示納米混懸劑粒徑均一。姜黃素納米混懸劑溶液和固化姜黃素納米混懸劑的體外累積溶出度明顯高于姜黃素原料藥。結(jié)論:高壓均質(zhì)法制備姜黃素納米混懸劑的工藝簡(jiǎn)單易行,姜黃素納米混懸劑能顯著提高藥物的體外溶出度。
[Abstract]:Objective: to prepare curcumin nano-suspension and study its dissolution in vitro. Methods: curcumin nano-suspension was prepared by high pressure homogenization method. The particle size distribution of curcumin nano-suspension was determined by PD I and Zeta potential. The influence factors of curcumin nano-suspension were investigated, the prepared nano-suspension was characterized, and the curcumin nano-suspension solution was compared. Results: the average particle size of curcumin nano-suspension was 396.4 鹵67.2 nmdI, the Zeta potential of curcumin nano-suspension was 0.369 鹵0.061, the Zeta potential of curcumin nano-suspension was -16.7 鹵3.5mV, scanning electron microscope showed that the particle size of nano-suspension was the same and curcumin nano-suspension was the same as that of curcumin nano-suspension, the average particle size of curcumin nano-suspension was 396.4 鹵67.2nmdI, and the Zeta potential of curcumin nano-suspension was -16.7 鹵3.5mV. The cumulative dissolution of curcumin nano-suspension and curcumin nano-suspension in vitro was significantly higher than that of curcumin raw material. Conclusion: the preparation of curcumin nano-suspension by high-pressure homogenization is simple and feasible. Curcumin nano-suspension can significantly improve the dissolution of drugs in vitro.
【作者單位】： 陜西中醫(yī)藥大學(xué);咸陽職業(yè)技術(shù)學(xué)院;
【基金】：陜西省科技廳計(jì)劃項(xiàng)目(2015SF203) 陜西省中藥制藥重點(diǎn)學(xué)科資助項(xiàng)目
【分類號(hào)】：R943

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 熊若蘭;陸偉根;;納米混懸劑研究進(jìn)展[J];世界臨床藥物;2007年02期

2 吳大鵬;陶濤;;靜脈注射用納米混懸劑[J];藥學(xué)服務(wù)與研究;2010年03期

3 孫曉革;;納米混懸劑及其制劑研究進(jìn)展[J];中國(guó)藥業(yè);2010年13期

4 蒲曉輝;張曉;孫進(jìn);何仲貴;;納米混懸劑的應(yīng)用及體內(nèi)外行為研究進(jìn)展[J];東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2011年04期

5 肖俊峰;唐石山;;復(fù)方爐甘石混懸劑的制備和質(zhì)量控制方法[J];中國(guó)藥業(yè);2013年17期

6 程曉丹;王永祿;李學(xué)明;黃琴琴;王悅;毛利娟;;紫杉醇納米混懸劑的制備與表征[J];華西藥學(xué)雜志;2011年02期

7 袁慧玲;易加明;張彩云;魯傳華;陳衛(wèi)東;;納米混懸劑的制備方法及給藥途徑研究進(jìn)展[J];中國(guó)新藥雜志;2014年03期

8 李非;宋雙雙;劉韻;郭迎新;潘衛(wèi)三;楊星鋼;;纈沙坦納米混懸劑的制備及其體外溶出度考察[J];藥學(xué)學(xué)報(bào);2013年08期

9 雷伯陽;;百菌清混懸劑局部刺激作用的研究[J];農(nóng)藥;1986年06期

10 黃茂莘;;爐甘石呋喃西林混懸劑的制備及質(zhì)量控制[J];中國(guó)現(xiàn)代應(yīng)用藥學(xué);2008年S2期

相關(guān)碩士學(xué)位論文 前2條

1 楊蘭俠;2-甲氧基雌二醇注射混懸劑的研究[D];鄭州大學(xué);2014年

2 陳昂;加蘭他敏緩釋混懸劑的研制[D];上海醫(yī)藥工業(yè)研究院;2006年

，

本文編號(hào)：1640293