本文選題：抗生素　切入點(diǎn)：活性氧(ROS)　出處：《科技通報(bào)》2017年03期 　論文類型：期刊論文

【摘要】：抗生素可誘導(dǎo)細(xì)菌產(chǎn)生活性氧(ROS)而造成氧化損傷,ROS的積累可以增強(qiáng)抗生素的殺菌效果。因此,抗生素作用下細(xì)菌死亡機(jī)制除抗生素作用特異性靶點(diǎn)而產(chǎn)生的選擇性毒力外,還包括ROS氧化損傷產(chǎn)生的非選擇性毒力。細(xì)菌通過(guò)自身抗氧化系統(tǒng)(OxyR、SoxRS及PerR)的調(diào)控機(jī)制促進(jìn)ROS清除、修復(fù)氧化損傷以響應(yīng)抗生素引起的ROS增加。本文對(duì)抗生素作用下胞內(nèi)ROS的產(chǎn)生機(jī)制和細(xì)菌對(duì)氧化損傷的響應(yīng)機(jī)制進(jìn)行綜述。
[Abstract]:Antibiotics can induce bacteria to produce reactive oxygen species (Ros) and cause oxidative damage. The accumulation of Ros can enhance the bactericidal efficacy of antibiotics. Therefore, the mechanism of bacterial death induced by antibiotics is not only the selective virulence produced by specific targets of antibiotics, but also by the accumulation of Ros. It also includes the non-selective virulence produced by oxidative damage of ROS. Bacteria promote ROS scavenging through the regulatory mechanisms of OxyRX RS and Perr. In order to repair oxidative damage in response to the increase of ROS induced by antibiotics, the mechanism of intracellular ROS production and the response of bacteria to oxidative damage were reviewed in this paper.
【作者單位】： 浙江工業(yè)大學(xué)生物工程學(xué)院;
【基金】：長(zhǎng)三角綠色制藥協(xié)同創(chuàng)新中心協(xié)同科研項(xiàng)目
【分類號(hào)】：R978.1

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本文編號(hào)：1638048