發(fā)布時(shí)間：2018-03-17 14:14

  本文選題：銀杏辛烯基琥珀酸淀粉酯　切入點(diǎn)：紫杉醇　出處：《食品與生物技術(shù)學(xué)報(bào)》2017年01期 　論文類型：期刊論文

【摘要】：以銀杏辛烯基琥珀酸淀粉酯為壁材,紫杉醇為芯材,采用噴霧干燥法制備微膠囊。通過正交試驗(yàn)確定了噴霧干燥法制備紫杉醇微膠囊的最優(yōu)工藝組合:紫杉醇與銀杏辛烯基琥珀酸淀粉酯質(zhì)量比例1∶8,乳狀液固形物質(zhì)量分?jǐn)?shù)15.0%,均質(zhì)壓力40.0 MPa,噴霧干燥進(jìn)風(fēng)溫度200℃。在此工藝條件下,紫杉醇包埋率為96.82%,微膠囊中紫杉醇質(zhì)量分?jǐn)?shù)為10.63%。產(chǎn)品氣味純正,沒有明顯的苦味,顆粒表面平整光滑,細(xì)小均勻,具有良好的流散性,包埋效果好。在模擬人工胃液中,90.0 min,累積溶出率4.27%,基本不釋藥;在模擬人工小腸液中,紫杉醇4.0 h的累積溶出率25.6%;在模擬人工大腸環(huán)境中,12.0 h的體外累積溶出率達(dá)89.26%,24.0 h的體外累積溶出率達(dá)95.34%。表明紫杉醇微膠囊具有抗酸、抗消化、在大腸中易降解等特性,達(dá)到了大腸定位釋藥的效果,且其制備工藝簡單、可行,是一種有潛力用于提高紫杉醇的藥效并且降低不良反應(yīng)的緩釋新劑型。
[Abstract]:Ginkgo biloba octenyl succinate starch ester was used as wall material and paclitaxel as core material. The optimum technology for the preparation of paclitaxel microcapsules by spray drying method was determined by orthogonal test: the mass ratio of paclitaxel to Ginkgo biloba octenyl succinate starch ester was 1: 8, and the emulsion solid substance was obtained. The volume fraction is 15.0, the homogenization pressure is 40.0 MPa, the inlet air temperature of spray drying is 200 鈩，

本文編號：1625099