本文選題：阿苯達(dá)唑　切入點(diǎn)：熱熔　出處：《中國醫(yī)藥工業(yè)雜志》2017年04期 　論文類型：期刊論文

【摘要】：正基于Flory-Huggins理論繪制阿苯達(dá)唑(ABZ)-聚合物的雙相混合物相圖,并用其評估共混相容性和可操作性。強(qiáng)制降解試驗(yàn)表明,ABZ在過氧化氫和1 mol/L氫氧化鈉溶液中80℃加熱5 min會(huì)發(fā)生降解,產(chǎn)物分別是阿苯達(dá)唑亞砜(ABZSX)和阿苯達(dá)唑雜質(zhì)A;而ABZ在1 mol/L鹽酸中即使于80℃加熱1 h也不會(huì)發(fā)生化學(xué)降解。熱降解分析表明,在存在和不存在Kollidon VA 64條件下,ABZ分別在180和140℃發(fā)生降解,提示ABZ可耐受熱處理。采用熱熔擠出法制備時(shí)ABZ降解了
[Abstract]:Based on the Flory-Huggins theory, the phase diagram of the two-phase mixture of albendazoline-polymer was drawn, and the compatibility and maneuverability of the blend were evaluated. The forced degradation test showed that the biodegradation of albendazolide at 80 鈩，

本文編號：1587789