發(fā)布時(shí)間：2018-02-27 05:25

  本文關(guān)鍵詞： 枸櫞酸坦度螺酮 自發(fā)性高血壓大鼠 內(nèi)皮功能　出處：《中國(guó)藥房》2017年22期 　論文類型：期刊論文

【摘要】：目的:研究枸櫞酸坦度螺酮(TC)對(duì)自發(fā)性高血壓大鼠(SHR)血壓的影響及機(jī)制。方法:將SHR隨機(jī)分為模型組、陽性對(duì)照組(苯磺酸左旋氨氯地平片,2.5 mg/kg)和TC高、中、低劑量組(TC膠囊,40、20、10 mg/kg),每組8只,另設(shè)8只正常大鼠為正常對(duì)照組,每天ig藥物1次,連續(xù)28 d。測(cè)量各組大鼠首次給藥前及給藥后0.5、1、1.5、2、3、4 h的收縮壓(SBP),另每給藥7 d測(cè)量1次1 h的SBP;末次給藥后檢測(cè)血清中一氧化氮(NO)含量,血漿中內(nèi)皮素、腎素、血管緊張素Ⅱ(AngⅡ)和去甲腎上腺素(NE)含量。結(jié)果:單次給藥時(shí),與模型組比較,陽性對(duì)照組和TC各劑量組SHR首次給藥后0.5、1 h時(shí)的SBP均明顯降低(P0.05或P0.01),之后僅陽性對(duì)照組和TC高劑量組的SBP明顯降低(P0.05或P0.01);多次給藥時(shí),與模型組比較,陽性對(duì)照組和TC高、中劑量組SHR給藥第7、14、28天的SBP均明顯降低(P0.05或P0.01)。與模型組比較,陽性對(duì)照組和TC高劑量組SHR血清中NO含量明顯升高,血漿中內(nèi)皮素、腎素、AngⅡ和NE含量均明顯降低(P0.05或P0.01);與陽性對(duì)照組比較,TC各劑量組SHR血清中NO含量明顯降低,TC中劑量組SHR血漿中內(nèi)皮素含量明顯升高(P0.05)。結(jié)論:TC可明顯降低SHR血壓,其機(jī)制可能與調(diào)節(jié)NO和內(nèi)皮素釋放平衡,降低腎素、AngⅡ及NE含量有關(guān)。
[Abstract]:Objective: to study the effect and mechanism of tandoxone citrate on blood pressure in spontaneously hypertensive rats. Methods: SHR was randomly divided into model group, positive control group (L-amlodipine benzenesulfonic acid 2.5 mg / kg) and high TC. In the low dose group, there were 8 rats in each group, 8 rats in each group, and 8 normal rats as control group. For 28 consecutive days, systolic blood pressure (SBP) was measured before and after the first administration of the drug, and the systolic blood pressure (SBP) was measured for 4 hours before and after the first administration of the drug, and 1 hour for every 7 days. The contents of nitric oxide (no) in serum, endothelin (et) and renin (renin) in plasma were measured after the last administration. Results: compared with the model group, the contents of angiotensin 鈪，

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