本文關(guān)鍵詞： 介孔二氧化硅納米粒 紫杉醇 體外釋放 抗腫瘤活性　出處：《中國(guó)藥科大學(xué)學(xué)報(bào)》2015年06期 　論文類型：期刊論文

【摘要】：介孔二氧化硅納米粒(mesoporous silica nanoparticle,MSN)作為藥物載體已成為納米給藥系統(tǒng)研究的熱點(diǎn)。以無(wú)序孔道的MSN為載體,以溶劑吸附法負(fù)載化療藥物紫杉醇(PTX),從而制備得到PTX@MSN。考察了PTX@MSN的理化性質(zhì)、藥物體外釋放行為和體外抗腫瘤活性等特性。研究結(jié)果表明,PTX@MSN載藥量為(23.76±1.14)%,在水性介質(zhì)中分散良好,粒徑約為250 nm,電位為-(8.01±1.81)mV。PTX@MSN具有藥物緩釋特性,24h后PTX累積釋放率為(23.62±2.15)%。細(xì)胞毒性結(jié)果顯示,空白MSN生物安全性良好,而PTX@MSN組對(duì)人肝癌HepG2細(xì)胞的殺傷作用較市售Taxol組強(qiáng)。本研究為MSN遞送抗腫瘤藥物提供一定的理論與應(yīng)用基礎(chǔ)。
[Abstract]:Mesoporous silica nanoparticles (mesoporous silica nanoparticlein MSN) as drug carriers have become a hot topic in the study of drug delivery systems. The chemotherapeutic drug paclitaxel (PTX) was prepared by solvent adsorption with disordered MSN as the carrier, and the physicochemical properties of PTX@MSN were investigated. The drug release behavior in vitro and anti-tumor activity in vitro were studied. The results showed that the drug load of PTX @ MSN was 23.76 鹵1.14%, and the drug was dispersed well in aqueous medium. The cumulative release rate of PTX was 23.62 鹵2.15% after 24 hours of sustained release. The cytotoxic results showed that the biological safety of blank MSN was good, and the potential was -8.01 鹵1.81mV.PTX @ MSN had the characteristics of sustained release of the drug for 24 hours, and the cumulative release rate of PTX was 23.62 鹵2.15g / min. The cytotoxic results showed that the biological safety of MSN was good. The killing effect of PTX@MSN group on human hepatoma HepG2 cells was stronger than that of commercial Taxol group. This study provides a theoretical and practical basis for the delivery of antitumor drugs by MSN.
【作者單位】： 中國(guó)藥科大學(xué)新藥研究中心江蘇省代謝性疾病藥物研究重點(diǎn)實(shí)驗(yàn)室;
【分類號(hào)】：R943

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