本文關(guān)鍵詞： 腦蛋白水解物 記憶鞏固 亞硝酸鈉　出處：《中國老年學(xué)雜志》2015年09期 　論文類型：期刊論文

【摘要】：目的觀察腦蛋白水解物對(duì)記憶鞏固障礙模型小鼠學(xué)習(xí)記憶能力的影響,探討其可能的作用機(jī)制。方法采用跳臺(tái)法觀察腦蛋白水解物對(duì)亞硝酸鈉記憶鞏固障礙模型小鼠學(xué)習(xí)記憶能力的影響,測(cè)定小鼠血清丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性與腦組織乙酰膽堿酯酶(ACh E)、Na+-K+-ATP、γ氨基丁酸酯(GABA)、MDA含量和SOD活性,并觀察小鼠腦組織海馬區(qū)病理形態(tài)學(xué)變化。結(jié)果腦蛋白水解物能延長小鼠潛伏期,減少錯(cuò)誤次數(shù);降低血清MDA含量,升高血清SOD活性;降低腦組織Na+-K+-ATP和ACh E含量,升高GABA含量;腦蛋白水解物對(duì)正常小鼠腦組織形態(tài)學(xué)無明顯影響,對(duì)記憶鞏固障礙模型小鼠腦組織有不同程度的修復(fù)作用。結(jié)論腦蛋白水解物能增強(qiáng)正常小鼠、改善亞硝酸鈉記憶鞏固障礙模型小鼠的學(xué)習(xí)記憶能力,可能與其減少自由基損傷有關(guān)。
[Abstract]:Objective to observe the effect of brain protein hydrolysate on learning and memory ability of mice with memory consolidation disorder. Methods the effect of brain protein hydrolysate on the learning and memory ability of mice with sodium nitrite memory consolidation disorder was studied. The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in serum and the activity of acetylcholinesterase (ach) in brain tissue were measured. The content of GABA and the activity of SOD were observed, and the pathomorphological changes of hippocampus of mice were observed. Results the brain protein hydrolysate could prolong the latency and decrease the number of errors in mice. The content of serum MDA was decreased and the activity of serum SOD was increased. The contents of Na K ATP and ACh E in brain tissue were decreased and GABA content was increased. The brain protein hydrolysate has no obvious effect on the morphology of brain tissue in normal mice, but it can repair the brain tissue of the model mice with memory consolidation disorder to varying degrees. Conclusion the hydrolysate of brain protein can enhance the brain tissue morphology of normal mice. The improvement of learning and memory ability of model mice with sodium nitrite memory consolidation disorder may be related to the reduction of free radical damage.
【作者單位】： 北華大學(xué)藥學(xué)院;
【基金】：吉林省衛(wèi)生計(jì)生科研計(jì)劃項(xiàng)目(20142088) 吉林省生物大分子功能開發(fā)與應(yīng)用工程實(shí)驗(yàn)室自主創(chuàng)新能力建設(shè)項(xiàng)目
【分類號(hào)】：R965
【正文快照】： 腦蛋白水解物是豬腦組織的提取物,含神經(jīng)營養(yǎng)因子、分子肽、氨基酸等活性成分〔1〕。研究表明,腦蛋白水解物易跨越血腦屏障,參與體內(nèi)氧化,增加腦活性〔2〕;作用于中樞神經(jīng)系統(tǒng),保護(hù)神經(jīng)細(xì)胞免受缺血、低氧、神經(jīng)毒素等損害〔3~6〕。目前,腦蛋白水解物片劑、注射液等治療阿爾茨

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本文編號(hào)：1486059