本文關(guān)鍵詞： D打印 阿司匹林 雙層片 釋放度　出處：《中國藥學(xué)雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的以阿司匹林為模型藥物,探討3D打印技術(shù)制備個體化需求的、可控釋放的阿司匹林片劑的可行性。方法實(shí)驗(yàn)選取羥丙基甲基纖維素10 000 m Pa·s(HPMC10000)和聚丙烯酸(PAA)作為緩釋層的親水性基質(zhì);羥丙基甲基纖維素100m Pa·s(HPMC100)作為速釋層黏合劑,羧甲基淀粉鈉(CMS-Na)和羥甲基淀粉鈉(SSG)作為速釋層的崩解劑,用3D打印機(jī)打印了阿司匹林速釋緩釋雙層片。選取100 mg·m L~(-1)聚乙烯吡咯烷酮(PVPK_(30))作為速釋層黏合劑,交聯(lián)羧甲基纖維素鈉(CCNa)作為速釋層崩解劑,HPMC100作為緩釋層的骨架材料,用傳統(tǒng)的壓片機(jī)壓制阿司匹林速釋緩釋雙層片,作為對比制劑�？疾�2種不同生產(chǎn)方式生產(chǎn)的片劑的物理化學(xué)性質(zhì)(片重差異、脆碎度、硬度和厚度)以及釋放曲線。結(jié)果 2種片劑的物理化學(xué)性質(zhì)均在藥典規(guī)定范圍內(nèi)。對比2種片劑釋放曲線可見,ASA-HPMC(14%,ω)打印片的釋放曲線與壓片雙層片相似,且釋放量高于壓片雙層片。ASA-HPMC(6%,ω)、ASA-HPMC(8%,ω)以及ASA-HPMC(10%,ω)打印片最終釋放量隨著親水性基質(zhì)HPMC的增加而增高。結(jié)論 3D打印機(jī)打印的不同形狀的片劑具有不同的釋放曲線,其中包合打印雙層片的釋放量高于其他片劑。
[Abstract]:Objective to explore the individualized requirements of 3D printing technology using aspirin as a model drug. Feasibility of controlled release aspirin tablets. Methods hydroxypropyl methyl cellulose (HPMC) and polyacrylic acid (PAA) were selected in the experiment. As the hydrophilic substrate of slow release layer; Hydroxypropyl methyl cellulose (HPMC100) was used as a quick release layer adhesive. Sodium carboxymethyl starch (CMS-Na) and sodium hydroxymethyl starch (SSG) were used as disintegrating agents for rapid release layer. The aspirin rapid release sustained release bilayer tablets were printed by 3D printer with 100mg 路mL ~ (-1) polyvinylpyrrolidone (PVPKK) as the fast release layer adhesive. Crosslinked carboxymethyl cellulose sodium (CCNA) was used as the rapid release layer disintegrating agent HPMC100 as the framework material of the sustained release layer, and the aspirin rapid release sustained release bilayer tablet was pressed by the traditional tablet press. As a contrast preparation, the physicochemical properties of the tablets produced in two different production methods were investigated. Results the physicochemical properties of the two tablets were within the range of pharmacopoeia. Compared with the two tablets, the release curves of ASA-HPMC could be seen in 14%. The release curve of 蠅) print film is similar to that of the double layer sheet, and the release amount is higher than that of the double layer sheet. ASA-HPMC6, 蠅 / ASA-HPMC8%. Omega) and ASA-HPMCN 10%. The final release amount of 蠅) printed tablets increased with the increase of hydrophilic matrix HPMC. Conclusion the release curves of different shapes of tablets printed by 3D printer are different. The release amount of inclusion printing bilayer was higher than that of other tablets.
【作者單位】： 浙江大學(xué)藥學(xué)院藥物制劑研究所;杭州市蕭山第四人民醫(yī)院;
【分類號】：R943;TP391.73
【正文快照】： 世界衛(wèi)生組織(WHO)1996年在題為《迎接21世紀(jì)的挑戰(zhàn)》的報告中指出,21世紀(jì)的醫(yī)學(xué)將從“疾病醫(yī)學(xué)”向“健康醫(yī)學(xué)”發(fā)展,從群體治療向個體治療發(fā)展,“個體化”的思想正逐步滲入到醫(yī)學(xué)實(shí)踐中。如何在常規(guī)治療的基礎(chǔ)上制造“私人”藥物也就顯得迫在眉睫。片劑是目前世界各國藥典收

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