本文關(guān)鍵詞：頭孢硫脒在小鼠的藥動(dòng)學(xué)研究　出處：《中國(guó)抗生素雜志》2015年05期 　論文類型：期刊論文

  更多相關(guān)文章： 頭孢硫脒 藥動(dòng)學(xué) LC-MS/MS 血漿

【摘要】：目的研究頭孢硫脒在小鼠中的藥動(dòng)學(xué)。方法取24只小鼠,隨機(jī)分為4組,每組6只,分別靜脈給予7.3、29.2、116.8和467.6mg/kg的頭孢硫脒,采集不同時(shí)間點(diǎn)的血樣,分離血漿,使用經(jīng)過(guò)確證的LC-MS/MS方法測(cè)定血漿中頭孢硫脒的濃度,用Win Nonlin軟件中的非房室模型計(jì)算藥動(dòng)學(xué)參數(shù)。結(jié)果靜脈給藥后,獲得的主要藥動(dòng)學(xué)參數(shù)如下:T1/2分別為(0.20±0.03)、(0.33±0.05)、(0.27±0.08)和(0.38±0.10)h;AUC0~∞分別為(2.85±0.63)、(11.31±1.71)、(53.38±17.57)和(374.9±134.7)h·mg/L;Cmax值分別為(9.53±2.10)、(46.67±9.50)、(170.18±71.02)和(1004.0±166.2)mg/L。結(jié)論本文建立了快速、靈敏測(cè)定小鼠血漿中頭孢硫脒的LC-MS/MS方法,并用于頭孢硫脒在小鼠中的藥動(dòng)學(xué)研究。藥動(dòng)學(xué)結(jié)果顯示,該藥體內(nèi)消除很快,不同劑量間的藥動(dòng)學(xué)參數(shù)呈現(xiàn)比較明顯的相關(guān)關(guān)系。
[Abstract]:Objective to study the pharmacokinetics of cefathiramidine in mice. Methods 24 mice were randomly divided into 4 groups with 6 rats in each group. 116.8 and 467.6 mg / kg cefathiamidine were collected, blood samples were collected at different time points, plasma was isolated, and the concentration of cefathiamidine in plasma was determined by confirmed LC-MS/MS method. The pharmacokinetic parameters were calculated by using the non-atrioventricular model of Win Nonlin software. Results after intravenous administration, the main pharmacokinetic parameters were as follows: T1 / 2 was 0.20 鹵0.03). (0. 33 鹵0. 05) and 0. 38 鹵0. 10 hs, 0.27 鹵0. 08) and 0. 38 鹵0. 10 hs respectively. The AUC _ 0 ~ 鈭，

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