本文關(guān)鍵詞：骨水泥載萬(wàn)古霉素超聲低頻脈沖型治療的起始時(shí)間對(duì)藥動(dòng)藥效產(chǎn)生的影響分析　出處：《中國(guó)醫(yī)院藥學(xué)雜志》2015年03期 　論文類型：期刊論文

  更多相關(guān)文章： 低頻脈沖超聲 萬(wàn)古霉 骨水泥 藥動(dòng)學(xué)

【摘要】：目的:研究低頻脈沖超聲治療的起始時(shí)間對(duì)載萬(wàn)古霉素骨水泥的藥物動(dòng)力學(xué)、藥效釋放以及抗菌活性的影響。方法:選擇50只健康大鼠,在大鼠髖關(guān)節(jié)均植入載萬(wàn)古霉素的骨水泥以及標(biāo)準(zhǔn)金黃色葡萄球菌(ATCC13565,中國(guó)生物鑒定研究所),隨后將50只大鼠隨機(jī)分成觀察組、對(duì)照組,觀察組在植入后12 h進(jìn)行低頻超聲治療,對(duì)照組在植入后30 min進(jìn)行低頻超聲治療,兩組均治療12 h后取4只大鼠測(cè)定髖關(guān)節(jié)內(nèi)的滲血量,其余大鼠測(cè)定髖關(guān)節(jié)內(nèi)的藥物濃度,計(jì)算藥物動(dòng)力及藥效參數(shù),在植入48 h后計(jì)數(shù)髖關(guān)節(jié)腔內(nèi)的活菌量并進(jìn)行組間比較。結(jié)果:觀察組、對(duì)照組均在植入3 h后達(dá)到藥物濃度高峰,對(duì)照組3 h后藥物濃度呈明顯的下降態(tài)勢(shì),并在14 h后下降到MIC以下,觀察組在3 h后也呈下降態(tài)勢(shì),但在12 h采用低頻超聲治療后,藥物濃度再次上升,并一直持續(xù)在MIC以上至第34小時(shí);觀察組Cmax/MIC(5.58±1.86)明顯低于對(duì)照組的(14.81±2.41),差異具有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組Tmic(35.08±5.98)h明顯高于對(duì)照組的(13.49±1.49)h,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);對(duì)照組菌落數(shù)、滲血量明顯高于觀察組(P0.05)。結(jié)論:與植入后立即進(jìn)行超聲治療相比,在第12小時(shí)進(jìn)行治療能夠有效提高血液的Tmic,提高載萬(wàn)古霉素骨水泥的抗菌作用。
[Abstract]:Objective: to study the effect of the initial time of low-frequency pulsed ultrasound on pharmacokinetics, pharmacokinetics, release and antibacterial activity of bone cement loaded with vancomycin. Methods: 50 healthy rats were selected. Bone cement loaded with vancomycin and standard staphylococcus aureus ATCC 13565 were implanted into the hip joints of the rats, and then 50 rats were randomly divided into observation group. The control group was treated with low-frequency ultrasound 12 hours after implantation, while the control group was treated with low-frequency ultrasound 30 min after implantation. After 12 hours of treatment, 4 rats in both groups were taken to determine the amount of blood oozing in the hip joint, and the other rats measured the drug concentration in the hip joint, and calculated the pharmacokinetic and pharmacodynamic parameters. After 48 hours of implantation, the live bacteria in the hip joint were counted and compared among the groups. Results: in the observation group and the control group, the concentration of the drug reached the peak 3 h after implantation. The drug concentration in the control group decreased significantly after 3 h, and decreased below MIC after 14 h, and decreased in the observation group after 3 h, but after 12 h treatment with low frequency ultrasound. The drug concentration increased again and lasted from above to 34 hours after MIC. Cmax/MIC(5.58 鹵1.86 in the observation group was significantly lower than that in the control group (14.81 鹵2.41), and the difference was statistically significant (P 0.05). The Tmic(35.08 of the observation group was significantly higher than that of the control group (13.49 鹵1.49 h), and the difference was statistically significant (P 0.05). The number of colony in the control group was significantly higher than that in the observation group (P 0.05). Conclusion: compared with the ultrasound treatment immediately after implantation, the Tmic of blood can be effectively increased after 12 hours of treatment. The antibacterial effect of vancomycin loaded bone cement was improved.
【作者單位】： 山西醫(yī)科大學(xué)藥學(xué)院;北京大學(xué)腫瘤醫(yī)院暨北京市腫瘤防治研究所藥劑科;山西醫(yī)科大學(xué)第一臨床醫(yī)院;
【分類號(hào)】：R965
【正文快照】： 術(shù)后關(guān)節(jié)感染是人工髖關(guān)節(jié)置換術(shù)常見(jiàn)的并發(fā)癥,嚴(yán)重威脅植入關(guān)節(jié)的功能,全身大劑量使用抗生素不能有效地提高抗生素在髖關(guān)節(jié)部位的局部濃度,還可能產(chǎn)生耐藥和腎毒性[1]�？股毓撬嗉夹g(shù)是1970年Buchholz等首次嘗試應(yīng)用于控制關(guān)節(jié)感染,將抗生素混合于用于植入的骨水泥鑄件中,

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 孫長(zhǎng)根;陳海峰;陳春;李賀;魏波;王宸;;不同時(shí)相抗生素骨水泥的釋放特性研究[J];東南大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2012年04期

相關(guān)博士學(xué)位論文 前1條

1 蔡迅梓;雙磷酸鹽及低頻超聲在骨水泥應(yīng)用中的特殊作用研究[D];浙江大學(xué);2012年

【二級(jí)參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李鋒,段軍,陳安民,廖輝;局部運(yùn)用阿侖磷酸鈉對(duì)兔人工假體無(wú)菌性松動(dòng)抑制作用的研究[J];生物骨科材料與臨床研究;2003年01期

2 王裕民,李欣,王敬強(qiáng),郭術(shù)勇;全髖關(guān)節(jié)置換術(shù)后假體松動(dòng)的預(yù)防研究[J];天津醫(yī)藥;2005年08期

3 胡建華,張良,孫常太,黃公怡;阿侖膦酸鈉對(duì)骨小梁力學(xué)特性的作用[J];中國(guó)骨質(zhì)疏松雜志;2003年01期

4 胡建華,黃公怡,丁銘;阿侖膦酸鈉對(duì)骨小梁結(jié)構(gòu)特性的作用[J];中華骨科雜志;2001年09期

5 邢智慶,馬忠泰,李子榮,施學(xué)東,王代樹(shù),梁云燕;阿侖膦酸鈉局部持續(xù)使用防治人工關(guān)節(jié)無(wú)菌性松動(dòng)可行性的細(xì)胞學(xué)研究[J];中華骨科雜志;2001年09期

6 范衛(wèi)民,陳曦,李翔;抗生素骨水泥物理和力學(xué)性能及洗提特性的實(shí)驗(yàn)研究[J];中華骨科雜志;2003年06期

7 張樹(shù)棟;譚江威;曲廣運(yùn);吳子培;;不同溫度保存單體在不同環(huán)境溫度下聚合的骨水泥抗疲勞性能比較[J];中華骨科雜志;2005年11期

8 嚴(yán)世貴;蔡迅梓;張建良;吳浩波;;低頻超聲對(duì)萬(wàn)古霉素骨水泥藥物釋放的影響[J];中華骨科雜志;2006年03期

9 蔣W，

本文編號(hào)：1425068