本文關(guān)鍵詞：中藥血清藥物化學(xué)研究概況及其理論和方法拓展，由筆耕文化傳播整理發(fā)布。

中藥血清藥物化學(xué)研究概況及其理論和方法拓展

Progress of serum pharmacochemistry of traditional Chinese medicine and further development of its theory and method

[1] [2] [3] [4] [5] [6] [7] [8]

YAN Guang-li, SUN Hui, ZHANG Ai-hua, HAN Ying, WANG Ping, WU Xiu-hong, MENG Xiang-cai, WANG Xi-jun （National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemis

黑龍江中醫(yī)藥大學(xué)國家中醫(yī)藥管理局中藥血清藥物化學(xué)重點研究室,黑龍江哈爾濱150040

文章摘要：中藥血清藥物化學(xué)是從中藥/方劑口服給藥后的血中移行成分中篩選藥效物質(zhì)基礎(chǔ)的研究設(shè)計,其理念及方法符合中藥整體作用模式,并體現(xiàn)了人體對藥物的代謝、轉(zhuǎn)化作用和藥物在體內(nèi)的相互作用,現(xiàn)已成為公認并被普遍應(yīng)用的研究中藥藥效物質(zhì)基礎(chǔ)的有效方式。該文對以往中藥血清藥物化學(xué)的研究內(nèi)容和研究方法進行梳理,在進一步認識中藥復(fù)方給藥形式的特殊性及方證對應(yīng)療效的專屬性基礎(chǔ)上,提出整合系統(tǒng)生物學(xué)的中藥血清藥物化學(xué)新研究策略：以證候為切入點,以方劑為研究對象,在利用系統(tǒng)生物學(xué)方法闡明證候生物標記物的前提下,評價方劑整體效應(yīng),在有效的狀態(tài)下,篩選與效應(yīng)生物標記物高度關(guān)聯(lián)的中藥血清移行成分,發(fā)現(xiàn)并確定中藥的藥效物質(zhì)基礎(chǔ)。通過整合系統(tǒng)生物學(xué)方法,中藥血清藥物化學(xué)的理論與方法進一步擴展,將開啟詮釋中醫(yī)藥理論的新篇章。

Abstr：Serum pharmacochemistry of traditional Chinese medicine（ TCM） is designed to screen the efficacy material base of TCMs from the constituents absorbed into the blood after oral administration. The theory and method is in accordance with the effect characteristics of TCMs,and reflects the interaction between the body and the drugs,has become an effective pathway for researching the efficacy material base of TCMs which has been recognized and used widely. In the paper,the previous research contents and methods of the serum pharmacochemistry of TCM were reviewed,and on the basis of the further validity of the special administration form of the TCM formula and the corresponding property to TCM syndrome,the new strategy of serum pharmacochemistry of TCM integrating the metabonomics technologies was put forward. According to the strategy,we take the biological characters of TCM syndrome as a research starting point,taking TCM formula as object,using the metabolic biomarkers of syndromes or disease to evaluate the therapeutic effect of formula and screen the compounds of TCMs in serum which are highly correlated with the metabolic biomarkers through the correlation analysis,and by further biological validation to finally confirm the efficacy material basis of TCMs. Integrating with the systems biology technologies,the theory and method of serum pharmacochemistry of TCM will further develop,and open a new chapter in the interpretation of the theory of TCM.

文章關(guān)鍵詞：

Keyword：:serum pharmacochemistry of traditional Chinese medicine efficacy material base formula systems biology future development

課題項目：國家自然科學(xué)基金重點項目（81430093）;國家自然科學(xué)基金面上項目（81173500,81373930,81473584）;國家自然科學(xué)基金青年基金項目（81202639,81302905）

  本文關(guān)鍵詞：中藥血清藥物化學(xué)研究概況及其理論和方法拓展，由筆耕文化傳播整理發(fā)布。