本文關(guān)鍵詞：微透析技術(shù)在中藥成分體內(nèi)分析研究中的應(yīng)用，由筆耕文化傳播整理發(fā)布。

微透析技術(shù)在中藥成分體內(nèi)分析研究中的應(yīng)用

Application of microdialysis technique in in vivo analysis on ingredients of Chinese materia medica

[1] [2] [3] [4]

DONG Ran-ran, WANG Meng, LIU Zhi-dong, ZHU Yan（ 1. Tianjin State Key Laboratory of Modern Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery

[1]天津中醫(yī)藥大學(xué),天津市現(xiàn)代重點(diǎn)實(shí)驗(yàn)室.省部共建國家重點(diǎn)實(shí)驗(yàn)室培育基地,現(xiàn)代中藥發(fā)現(xiàn)與制劑技術(shù)教育部工程研究中心,天津300193; [2]天津國際生物醫(yī)藥聯(lián)合研究院,天津300457

文章摘要：中藥及其制劑成分復(fù)雜,經(jīng)過吸收分布后機(jī)體內(nèi)成分的量較低,由于傳統(tǒng)的生物樣品取樣方法存在多種不足,影響中藥成分體內(nèi)過程研究,從而對(duì)中藥藥效物質(zhì)基礎(chǔ)研究造成影響。微透析技術(shù)作為一種簡便、靈敏的取樣技術(shù),在線結(jié)合高效液相色譜、質(zhì)譜等分析技術(shù),可動(dòng)態(tài)揭示中藥成分及其代謝產(chǎn)物在機(jī)體內(nèi)的分布變化規(guī)律,極大程度提高了中藥活性成分體內(nèi)分析精度,降低實(shí)驗(yàn)動(dòng)物損傷。主要介紹微透析技術(shù)的原理、系統(tǒng)組成、特點(diǎn),重點(diǎn)介紹了其在中藥成分體內(nèi)分析研究中的應(yīng)用。微透析技術(shù)的應(yīng)用有利于闡明中藥藥效物質(zhì)基礎(chǔ)及其體內(nèi)過程,有利于中藥靶向給藥傳遞系統(tǒng)的開發(fā),在中藥現(xiàn)代化研究中具有廣泛的應(yīng)用前景。

Abstr：Due to the complications of Chinese materia medica（CMM） and its preparations, traditional sampling methods have some limitations and affect the analysis on the ingredients of CMM. The review mainly introduced the principles, system compositions, characteristics of the microdialysis technique according to 70 literatures in the late 10 years, especially its applications on the analysis on CMM in vivo, such as in brain, skin, blood, eyes, intestinal, joint, liver, gallbladder kidney, and lung. Among these organs, brain and skin studies have more experiences. As a sampling method, microdialysis technique can not only reveal the change process of ingredients in CMM, but also can help the development of targeted drug delivery, which has the great value and good perspective in the modernization study on CMM.

文章關(guān)鍵詞：

Keyword：:microdialysis technique Chinese materia medica in vivo analysis pharmacodynamic material basis targeted drug delivery system

  本文關(guān)鍵詞：微透析技術(shù)在中藥成分體內(nèi)分析研究中的應(yīng)用，由筆耕文化傳播整理發(fā)布。