本文選題：絕經(jīng)前 + 絕經(jīng)后��； 參考：《中國(guó)動(dòng)脈硬化雜志》2017年08期

【摘要】：目的探討絕經(jīng)前后女性冠心病患者高密度脂蛋白(HDL)顆粒及低密度脂蛋白(LDL)顆粒與冠狀動(dòng)脈病變程度的關(guān)系。方法收集經(jīng)冠狀動(dòng)脈造影確診的女性冠心病患者79例,根據(jù)是否絕經(jīng)分為絕經(jīng)前組(n=37)和絕經(jīng)后組(n=42)。Lipoprint脂蛋白分析儀對(duì)HDL顆粒及LDL顆粒進(jìn)行檢測(cè)分析,探討兩種脂蛋白顆粒與冠狀動(dòng)脈病變程度的關(guān)系。結(jié)果與絕經(jīng)前組比較,絕經(jīng)后組大顆粒HDL濃度(102.6±45.2 mg/L比143.8±49.7 mg/L,P0.05)及所占比例(23.34%±8.26%比31.15%±7.98%,P0.05)、LDL顆粒平均直徑(259.5±8.1姒比265.7±3.7姒,P0.05)均降低,小顆粒HDL濃度(124.0±76.8 mg/L比87.0±34.9 mg/L,P0.05)及所占比例(27.26%±12.34%比18.62%±6.53%,P0.05)、LDL B型比例(73.8%比48.6%,P0.05)、Gensini積分(50.88±26.46比30.43±18.54,P0.05)均增高。絕經(jīng)前組及絕經(jīng)后組多支病變患者大顆粒HDL濃度、LDL顆粒平均直徑均低于單支病變患者,Gensini積分高于單支病變患者;絕經(jīng)后組大顆粒HDL濃度、LDL顆粒平均直徑均低于絕經(jīng)前組,小顆粒HDL所占比例及Gensini積分高于絕經(jīng)前組。絕經(jīng)前組和絕經(jīng)后組LDL顆粒大小及大顆粒HDL濃度均與Gensini積分呈負(fù)相關(guān)。結(jié)論與絕經(jīng)前組相比,絕經(jīng)后組大顆粒HDL濃度較低,小顆粒HDL濃度較高,LDL顆粒平均直徑較小,冠狀動(dòng)脈病變程度較嚴(yán)重;大顆粒HDL濃度及LDL平均直徑與冠狀動(dòng)脈病變嚴(yán)重程度明顯相關(guān)。
[Abstract]:Objective to investigate the relationship between high density lipoprotein (HDL) granules and low density lipoprotein (LDL) granules and the severity of coronary artery disease in premenopausal and postmenopausal women with coronary heart disease. Methods 79 female patients with coronary heart disease diagnosed by coronary angiography were divided into premenopausal group and postmenopausal group according to whether they were divided into premenopausal group and postmenopausal group. The HDL granules and LDL granules were detected by Lipoprint lipoprotein analyzer. To investigate the relationship between two kinds of lipoprotein granules and the severity of coronary artery disease. Results compared with the premenopausal group, the HDL concentration of large particles in the postmenopausal group was 102.6 鹵45.2 mg/L vs 143.8 鹵49.7 mg / L P0.05), and the average diameter of the large particles was 23.34% 鹵8.26% vs 31.15% 鹵7.98% 鹵7.98% 鹵7.98 鹵7.95 鹵8.15 vs 265.7 鹵3.7Si (P 0.05) in the postmenopausal group. The HDL concentration of small particles (124.0 鹵76.8 mg/L vs 87.0 鹵34.9 mg / L P0.05) and the ratio of 27.26% 鹵12.34% to 18.62% 鹵6.53% were higher than that of P0.05Gensini integral (50.88 鹵26.46 vs 30.43 鹵18.54 P0.05). In premenopausal and postmenopausal multivessel lesion patients, the mean diameter of large particle HDL particles was lower than that of single vessel lesion group, and the mean diameter of large particle HDL particles in postmenopausal group was lower than that in premenopausal group, and the mean diameter of large particle HDL in postmenopausal group was lower than that in premenopausal group. The proportion of HDL and Gensini score of small particles were higher than that of premenopausal group. The size of LDL particles and HDL concentration of large particles were negatively correlated with Gensini scores in premenopausal and postmenopausal groups. Conclusion compared with premenopausal group, postmenopausal group has lower HDL concentration, higher HDL concentration, smaller mean diameter and more severe coronary artery lesion. The concentration of HDL and the mean diameter of LDL were significantly correlated with the severity of coronary artery disease.
【作者單位】： 山西醫(yī)科大學(xué);山西醫(yī)科大學(xué)第二醫(yī)院心內(nèi)科心血管疾病診治及臨床藥理山西省重點(diǎn)實(shí)驗(yàn)室;山西醫(yī)科大學(xué)第一醫(yī)院特需病房;山西醫(yī)科大學(xué)第一醫(yī)院心內(nèi)科;
【分類號(hào)】：R541.4

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