【摘要】：目的比較人臍帶血干細(xì)胞經(jīng)外周靜脈、肝動(dòng)脈移植治療失代償期肝硬化的患者近期療效。方法將該院2010年1月-2014年4月收治的40例肝硬化失代償期患者隨機(jī)分成兩組,每組20例。在內(nèi)科綜合治療的基礎(chǔ)上,分別經(jīng)外周靜脈和經(jīng)股動(dòng)脈穿刺至肝固有動(dòng)脈,移植相同數(shù)量的人臍帶血干細(xì)胞,觀察兩組患者術(shù)后臨床癥狀變化,檢測(cè)術(shù)后2、4、8和12周患者血清總膽紅素(TBIL)、谷丙轉(zhuǎn)氨酶(ALT)、谷草轉(zhuǎn)氨酶(AST)、血清蛋白(ALB)、膽堿酯酶(CHE)、凝血酶原時(shí)間(PT)水平。結(jié)果兩組在治療后2周左右患者臨床癥狀改善,術(shù)后4周兩組總膽紅素、ALT、AST開始逐漸下降,血清白蛋白、膽堿酯酶逐漸上升,凝血酶原時(shí)間縮短,與術(shù)前比較差異有統(tǒng)計(jì)學(xué)意義。但外周靜脈移植組各檢測(cè)指標(biāo)在術(shù)后8周與術(shù)后12周比較差異無統(tǒng)計(jì)學(xué)意義。經(jīng)肝動(dòng)脈組患者總膽紅素、ALT、AST、血清白蛋白等指標(biāo)改善呈時(shí)間依賴性,至術(shù)后12周時(shí)最明顯,而凝血酶原時(shí)間術(shù)后8周和12周差異無統(tǒng)計(jì)學(xué)意義。結(jié)論經(jīng)外周靜脈、肝動(dòng)脈移植人臍帶血干細(xì)胞治療肝硬化失代償期患者近期療效確切,且經(jīng)肝動(dòng)脈移植人臍帶血干細(xì)胞有時(shí)間依賴性。
[Abstract]:Objective to compare the short-term effect of human umbilical cord blood stem cell transplantation via peripheral vein in the treatment of decompensated cirrhosis. Methods from January 2010 to April 2014, 40 patients with decompensated cirrhosis were randomly divided into two groups, 20 patients in each group. On the basis of comprehensive medical treatment, the same number of human umbilical cord blood stem cells were transplanted into the proper hepatic artery via peripheral vein and femoral artery respectively. The clinical symptoms of the two groups were observed after operation. Serum total bilirubin (TBIL), glutamate-alanine aminotransferase (ALT),) and serum (ALB), cholinesterase (CHE),) prothrombin time (PT) were measured at 2 and 12 weeks after operation. Results after 2 weeks of treatment, the clinical symptoms of the two groups were improved, the total bilirubin and alt AST began to decrease gradually, the serum albumin and cholinesterase increased gradually, the prothrombin time was shortened, and there was a significant difference between the two groups. However, there was no significant difference between 8 weeks and 12 weeks after operation in peripheral vein transplantation group. The improvement of total bilirubin alt AST and serum albumin in transhepatic artery group was time-dependent and was most obvious at 12 weeks after operation but there was no significant difference in prothrombin time between 8 and 12 weeks after operation. Conclusion Transplantation of human umbilical cord blood stem cells via peripheral vein and hepatic artery is effective in the treatment of patients with decompensated cirrhosis in the short term, and the transplantation of human umbilical cord blood stem cells through hepatic artery is time-dependent.
【作者單位】： 南華大學(xué)附屬第二醫(yī)院消化內(nèi)科;南華大學(xué)附屬第二醫(yī)院重癥醫(yī)學(xué)科;
【分類號(hào)】：R575.2

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