本文選題：HLA-DQA1 + HLA-DQB1　； 參考：《華北理工大學》2017年碩士論文

【摘要】：目的通過對涉及HLA-Ⅱ類基因多態(tài)性與H.pylori感染相關(guān)性的文獻進行Meta分析,證明二者之間有無聯(lián)系,揭示遺傳因素中HLA-Ⅱ類基因?qū).pylori感染是否存在影響。方法檢索中英文數(shù)據(jù)庫,包括中國知網(wǎng)、萬方、維普、中國生物醫(yī)學文獻數(shù)據(jù)庫、PUBMED、MEDLINE、OVID、COCHRANE等醫(yī)學數(shù)據(jù)庫。檢索時間范圍1995年1月—2016年6月。檢索的文獻涉及HLA-Ⅱ類基因多態(tài)性與H.pylori感染的關(guān)系。根據(jù)制定的納入排除標準,對檢索到的文獻進行篩檢。仔細閱讀篩檢后納入的文獻,進行數(shù)據(jù)提取和質(zhì)量評價。數(shù)據(jù)提取時將需要進行Meta分析的數(shù)據(jù)分為H.pylori感染組(病例組)和H.pylori未感染組(對照組);質(zhì)量評價則按照STREGA報告規(guī)范進行量化評分,3分文獻質(zhì)量過低。衡量結(jié)果的效應(yīng)指標有I2、Z值、P值、OR和95%CI。根據(jù)各位點的森林圖,制作Meta分析結(jié)果匯總表。行敏感性分析、亞組分析。繪制漏斗圖對發(fā)表偏倚進行定性評估,同時使用Egger’s法進行定量評估。結(jié)果1 DQA1共納入了16個基因位點,其中DQA1*0102位點,H.pylori感染組基因頻率低于H.pylori未感染組(P=0.0008,OR95%CI:0.72(0.59,0.87)),即DQA1*0102為抵抗H.pylori感染的抵抗基因。同時按地區(qū)的亞組分析顯示,DQA1*0102在亞洲地區(qū)(P=0.03,OR95%CI:0.68(0.49,0.96))是H.pylori感染的抵抗基因,而歐洲地區(qū)不再是抵抗基因(P=0.43)。DQA1*0103位點H.pylori感染組基因頻率高于H.pylori未感染組(P=0.009,OR95%CI:1.35(1.08,1.69)),即DQA1*0103是H.pylori感染的易感基因。DQA1*0104、0301位點是H.pylori感染的易感基因(P=0.0002,OR95%CI:1.95(1.37,2.76))、(P=0.04,OR95%CI:1.32(1.01,1.71))。但敏感性分析(改變統(tǒng)計學模型)后,DQA1*0104(P=0.06)、0301(P=0.11)位點不再是H.pylori感染的易感基因。2DQB1共納入了19個基因位點,其中DQB1*03032是避免H.pylori感染的抵抗基因(P=0.0003,OR95%CI:0.55(040,0.76)),并且納入的文獻地區(qū)都為亞洲,所以是亞洲人群的抵抗基因。DQB1*04、0401是H.pylori感染的易感基因(P=0.02,OR95%CI::2.56(1.14,5.75))、(P=0.0004,OR95%CI:1.87(1.32,2.65))。DQB1*0602、0604位點是H.pylori感染的抵抗基因(P=0.02,OR95%CI::0.69(0.50,0.94))、(P=0.0009,OR95%CI:0.50(0.30,0.84)),但敏感性分析(改變統(tǒng)計學模型)后,DQB1*0602、0604位點不再具有統(tǒng)計學差異(P=0.08)、(P=0.24)。3 DRB1共納入了38個基因位點,其中DRB1*08,11,二組比較(P=0.03,OR95%CI:1.61(1.05,2.49))、(P=0.04,OR95%CI:1.43(1.02,2.00)),說明DRB1*08是H.pylori感染的易感基因,但敏感性分析(改變統(tǒng)計學模型)后,DRB1*08、11不再是H.pylori感染的易感基因(P=0.07)、(P=0.10)。另外對DRB1*11位點進行亞組分析(按H.pylori診斷的方法分組)。使用聯(lián)合試驗診斷H.pylori的DRB1*11位點是否與H.pylori感染有關(guān)系,尚需更多的數(shù)據(jù)(P=0.05,OR95%CI:2.33(1.01,5.39))。DRB1*12位點,二組比較沒有統(tǒng)計學差異(P=0.28)。但經(jīng)亞組分析(按地區(qū))后,顯示亞洲地區(qū)DRB1*12為H.pylori感染的抵抗基因(P=0.04,OR95%CI:0.45(0.21,0.96))。歐洲地區(qū)DRB1*12是否與為H.pylori感染有關(guān)尚需更多數(shù)據(jù)(P=0.05,OR95%CI:2.62(0.99,6.90))。DRB1*1502位點亞組分析(按地區(qū))后,歐洲地區(qū)DRB1*1502是否與H.pylori感染有關(guān)系,尚需更多的數(shù)據(jù)(P=0.05,OR95%CI:3.15(0.98,10.15))。結(jié)論1 DQA1*0102與H.pylori感染存在相關(guān)性,是亞洲人群避免H.pylori感染的抵抗基因。2 DQA1*0103與H.pylori感染存在相關(guān)性,是H.pylori感染的易感基因。3 DQB1*04與H.pylori感染存在相關(guān)性,是H.pylori感染的易感基因。4DQB1*0401與H.pylori感染存在相關(guān)性,是H.pylori感染的易感基因。5在亞洲人群中DQB1*03032與H.pylori感染存在相關(guān)性,是避免H.pylori感染的抵抗基因。6尚未發(fā)現(xiàn)DRB1位點與H.pylori感染存在明確的相關(guān)性。
[Abstract]:Objective through Meta analysis of the literature related to the correlation between HLA- II gene polymorphism and H.pylori infection, it is proved that there is no connection between the two and the influence of the HLA- II gene on the H.pylori infection in the genetic factors. Methods the Chinese database, including the Chinese knowledge network, the Wanfang, VIP, and the Chinese biomedical literature database, is retrieved. Medical databases such as PUBMED, MEDLINE, OVID, COCHRANE, and other medical databases. Retrieval time range from January 1995 to June 2016. The documents retrieved involved the relationship between the HLA- type II gene polymorphism and H.pylori infection. According to the inclusion criteria formulated, the retrieved literature was screened. The documents included in the screening were carefully read, and the data were extracted and the quality was obtained. Meta analysis was divided into H.pylori infection group (case group) and H.pylori uninfected group (control group) when the data was extracted. The quality evaluation was quantified according to the STREGA report standard, and the quality of the 3 points was too low. The effect indexes of the results were I2, Z value, P value, OR and 95%CI. based on the forest map of each point, to make Meta. Analysis of the results of the analysis, line sensitivity analysis, subgroup analysis. Draw the funnel map to make a qualitative assessment of the publication bias, and use the Egger 's method for quantitative evaluation. Results 1 DQA1 included 16 gene loci, of which the DQA1*0102 locus, the H.pylori infection group was lower than the H.pylori uninfected group (P=0.0008, OR95%CI:0.72 (0.59,0.87)). DQA1*0102 is a resistance gene that resists H.pylori infection. According to regional subgroup analysis, DQA1*0102 is the resistance gene of H.pylori infection in Asia (P=0.03, OR95%CI:0.68 (0.49,0.96)), while the European region is no longer the resistance gene (P=0.43).DQA1*0103 point H.pylori infection group, and the gene frequency is higher than that of the H.pylori infection group (P=0.0). 09, OR95%CI:1.35 (1.08,1.69)), that is, DQA1*0103 is the susceptible gene of H.pylori infection, the.DQA1*01040301 locus is the susceptible gene of H.pylori infection (P=0.0002, OR95%CI:1.95 (1.37,2.76)), (P=0.04, OR95%CI:1.32 (1.01,1.71)). But after sensitivity analysis, the 0301 locus is no longer an infection. The susceptibility gene.2DQB1 is included in 19 loci, in which DQB1*03032 is the resistance gene to avoid H.pylori infection (P=0.0003, OR95%CI:0.55 (040,0.76)) and is included in the literature region for Asia, so the resistance gene.DQB1*040401 of the Asian population is the susceptible gene of H.pylori infection (P=0.02, OR95%CI:: 2.56 (1.14,5.75)), (P=0.). 0004, OR95%CI:1.87 (1.32,2.65)).DQB1*06020604 site is the resistance gene of H.pylori infection (P=0.02, OR95%CI:: 0.69 (0.50,0.94)), (P=0.0009, OR95%CI:0.50 (0.30,0.84)), but after sensitivity analysis (change statistical model), DQB1*06020604 loci no longer have statistical difference (P=0.08), including 38 gene loci. DRB1*08,11, two groups (P=0.03, OR95%CI:1.61 (1.05,2.49)), (P=0.04, OR95%CI:1.43 (1.02,2.00)), indicating that DRB1*08 is a susceptible gene for H.pylori infection, but after sensitivity analysis (change statistical model), DRB1*08,11 is no longer the susceptible gene of H.pylori infection (P=0.07). Ylori diagnostic methods. The use of a combined test to diagnose the DRB1*11 loci of H.pylori is associated with H.pylori infection, and more data (P=0.05, OR95%CI:2.33 (1.01,5.39)).DRB1*12 loci are needed, and there is no statistical difference between the two groups (P=0.28). However, the Asian region DRB1*12 is shown to be H.pylori infection after subdivision (according to the region). Resistance genes (P=0.04, OR95%CI:0.45 (0.21,0.96)). Whether DRB1*12 in Europe is related to H.pylori infection still needs more data (P=0.05, OR95%CI:2.62 (0.99,6.90)) subgroup analysis of.DRB1*1502 (according to region), whether DRB1*1502 in Europe is related to H.pylori infection and need more data (P=0.05,). Conclusion there is a correlation between 1 DQA1*0102 and H.pylori infection. It is the correlation between the resistance gene.2 DQA1*0103 of the Asian population to avoid H.pylori infection and the infection of H.pylori. The susceptibility gene of H.pylori infection is related to.3 DQB1*04 and H.pylori infection, and the susceptible basis of H.pylori infection is associated with.4DQB1*0401 and infection. The susceptibility gene.5 of H.pylori infection is associated with DQB1*03032 and H.pylori infection in Asian population. It is a resistance gene to avoid H.pylori infection,.6 has not yet found a clear correlation between the DRB1 locus and H.pylori infection.
【學位授予單位】：華北理工大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R573

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