【摘要】：[目的]：比較分別添加不同質(zhì)量分?jǐn)?shù)的三種納米抗菌劑硅橡膠在體外對(duì)白色念珠菌和金黃色葡萄球菌的抗菌性；比較添加相同質(zhì)量分?jǐn)?shù)的三種納米抗菌劑硅橡膠在體外對(duì)白色念珠菌和金黃色葡萄球菌抗菌效果的持久性；比較添加三種納米抗菌劑不同質(zhì)量分?jǐn)?shù)時(shí)對(duì)硅橡膠機(jī)械性能的影響。 [材料與方法]：第一部分：將納米TiO2、納米ZnO和Ag-TiO2按1.0%、2.0%、3.0%、4.0%、5.0%質(zhì)量比分別加入到硅橡膠中制成抗菌硅橡膠,采用薄膜覆蓋法檢測(cè)其對(duì)白色念珠菌和金黃色葡萄球菌的抗菌性能。第二部分：將質(zhì)量分?jǐn)?shù)為4.0%的三種抗菌劑分別添加到硅橡膠中,對(duì)其分別進(jìn)行兩種加速老化處理,采用浸漬培養(yǎng)法檢測(cè)新制備組和老化處理后抗菌硅橡膠的抗菌性能,比較其抗菌長(zhǎng)效性。第三部分：將納米Ti02、納米ZnO和Ag-TiO2按1.0%-5.0%質(zhì)量比分別加入到硅橡膠中,制備成抗菌硅橡膠,檢測(cè)其拉伸強(qiáng)度、撕裂強(qiáng)度、扯斷伸長(zhǎng)率和邵氏硬度,通過(guò)與空白對(duì)照組進(jìn)行比較,分析添加何種質(zhì)量分?jǐn)?shù)的抗菌劑對(duì)機(jī)械性能影響較小。 [結(jié)果]： 第一部分：添加三種納米無(wú)機(jī)抗菌劑的硅橡膠,對(duì)白色念珠菌和金黃色葡萄球菌均有抑制作用,當(dāng)添加質(zhì)量分?jǐn)?shù)在1.0%-4.0%范圍內(nèi),抗菌率隨著其質(zhì)量分?jǐn)?shù)的升高而增加；添加質(zhì)量分?jǐn)?shù)為5.0%時(shí),其抗菌率均出現(xiàn)不同程度的降低。 第二部分：添加質(zhì)量分?jǐn)?shù)為4.0%的三種抗菌劑硅橡膠,在體外經(jīng)過(guò)兩種加速老化處理后,與新制備組相比,對(duì)白色念珠菌和金黃色葡萄球菌的抗菌率有不同程度的降低。 第三部分：三種納米抗菌劑添加量在1.0%-5.0%的范圍內(nèi),抗菌性硅橡膠的拉伸強(qiáng)度和扯斷伸長(zhǎng)率,納米ZnO組和納米TiO2組呈先升高后降低的趨勢(shì),而Ag-TiO2呈逐漸降低的趨勢(shì)；將不同質(zhì)量分?jǐn)?shù)的三種抗菌劑分別加入到硅橡膠,撕裂強(qiáng)度均呈先升高后降低的趨勢(shì),硬度均表現(xiàn)為逐漸升高。 [結(jié)論]： 1.添加同一質(zhì)量分?jǐn)?shù)的三種抗菌劑,其抗菌硅橡膠的抗菌性能比較：Ag-TiO2納米TiO2納米ZnO；分別添加三種抗菌劑的硅橡膠,其添加質(zhì)量分?jǐn)?shù)為4.0%時(shí)抗菌效果為最優(yōu)。 2.添加質(zhì)量分?jǐn)?shù)為4.0%的納米ZnO和納米TiO2抗菌性硅橡膠具有抗菌長(zhǎng)效性,而Ag-Ti02抗菌性硅橡膠老化處理后抗菌性能略有降低。 3.通過(guò)檢測(cè)其對(duì)機(jī)械性能的影響得出：納米ZnO和納米TiO2的最適宜添加量為3.0%:Ag-Ti02的最適宜添加量為2.0%。
[Abstract]:[objective]: to compare the antibacterial activity of three kinds of nano-antimicrobial agents silicone rubber with different mass fraction against Candida albicans and Staphylococcus aureus in vitro. The effects of three kinds of nano-antimicrobial agents, silicone rubber with the same mass fraction, against Candida albicans and Staphylococcus aureus in vitro were compared, and the effects of three nano-antimicrobial agents on the mechanical properties of silicone rubber were compared. [materials and methods]: the first part: the antibacterial silicone rubber was prepared by adding the nano-TiO _ 2, ZnO and Ag-TiO _ 2 into the silicone rubber at the mass ratio of 2.0% to 4.0% and 5.0% respectively. The antibacterial properties against Candida albicans and Staphylococcus aureus were tested by thin film covering method. In the second part, three kinds of antimicrobial agents with a mass fraction of 4.0% were added to silicone rubber, and two kinds of accelerated aging treatments were carried out respectively. The antibacterial properties of the new preparation group and the aging treated silicone rubber were tested by impregnation culture method. To compare its long-term antibacterial effect. The third part: Nano-Ti02, nano-ZnO and Ag-TiO _ 2 were added to silicone rubber at the mass ratio of 1.0- 5.0% to prepare antibacterial silicone rubber. The tensile strength, tear strength, elongation at break and Shao's hardness were tested, and compared with the blank control group. The effect of the addition of antimicrobial agents on mechanical properties was analyzed. [results]: the first part: silicone rubber with three kinds of nano-inorganic antimicrobial agents had inhibitory effect on both Candida albicans and Staphylococcus aureus, when the mass fraction was in the range of 1.0-4.0%, The antibacterial rate increased with the increase of mass fraction, and decreased in varying degrees when the mass fraction was 5.0%. The second part: after two kinds of accelerated aging treatment in vitro, the antibacterial rate against Candida albicans and Staphylococcus aureus was decreased in different degree compared with the new preparation group. The third part: the tensile strength and elongation at break of the antibacterial silicone rubber were increased firstly and then decreased in the range of 1.0% -5.0% of the three nano-antibacterial agents, while Ag-TiO _ 2 decreased gradually. When three kinds of antimicrobial agents with different mass fraction were added to silicone rubber, the tear strength increased first and then decreased, and the hardness increased gradually. [conclusion]: 1. Comparison of antibacterial properties of three kinds of antimicrobial agents with the same mass fraction, the antibacterial effect of nano-TiO _ 2 nanocrystalline ZnO / Ag-TiO _ 2 was compared, and that of silicone rubber with the addition of three kinds of antimicrobial agents was the best when the mass fraction was 4.0. 2. Nano-ZnO and nano-TiO _ 2 antibacterial silicone rubber with 4.0% mass fraction had long-term antibacterial effect, while Ag-Ti02 antibacterial silicone rubber had a slight decrease in antibacterial property after aging treatment. The effects of nano-ZnO and nano-TiO _ 2 on mechanical properties were investigated. The optimum addition amount of nano-ZnO and nano-TiO _ 2 was 3.0 and 2.0 respectively.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R783.1

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