【摘要】：Biocompatibility is the basic requirement of biomaterials for tissue repair. However, the present concept of biocompatibility has a certain limitation in explaining the phenomena involved in biomaterial-based tissue repair. New materials, in particular those for tissue engineering and regeneration, have been developed with common characteristics, i.e. they participate deeply into important chemical and biological processes in the human body and the interaction between the biomaterials and tissues is far more complex.Understanding the interplay between these biomaterials and tissues is vital for their development and functionalization. Herein, we suggest the concept of bioadaptability of biomaterials. This concept describes the three most important aspects that can determine the performance of biomaterials in tissue repair: 1) the adaptability of the micro-environment created by biomaterials to the native microenvironment in situ; 2) the adaptability of the mechanical properties of biomaterials to the native tissue;3) the adaptability of the degradation properties of biomaterials to the new tissue formation. The concept of bioadaptability emphasizes both the material's characteristics and biological aspects within a certain micro-environment and molecular mechanism. It may provide new inspiration to uncover the interaction mechanism of biomaterials and tissues, to foster the new ideas of functionalization of biomaterials and to investigate the fundamental issues during the tissue repair process by biomaterials. Furthermore, designing biomaterials with such bioadaptability would open a new door for repairing and regenerating organs or tissues. In this review, we summarized the works in recent years on the bioadaptability of biomaterials for tissue repair applications.
[Abstract]:Biocompatibility is the basic requirement of biomaterials for tissue repair. However, the present concept of biocompatibility has a certain limitation in explaining the phenomena involved in biomaterial-based tissue repair. New materials, in particular those for tissue engineering and regeneration, have been developed with common characteristics, i.e. they participate deeply into important chemical and biological processes in the human body and the interaction between the biomaterials and tissues is far more complex.Understanding the interplay between these biomaterials and tissues is vital for their development and functionalization. Herein, we suggest the concept of bioadaptability of biomaterials. This concept describes the three most important aspects that can determine the performance of biomaterials in tissue repair: 1) the adaptability of the micro-environment created by biomaterials to the native microenvironment in situ; 2) the adaptability of the mechanical properties of biomaterials to the native tissue;3) the adaptability of the degradation properties of biomaterials to the new tissue formation. The concept of bioadaptability emphasizes both the material's characteristics and biological aspects within a certain micro-environment and molecular mechanism. It may provide new inspiration to uncover the interaction mechanism of biomaterials and tissues, to foster the new ideas of functionalization of biomaterials and to investigate the fundamental issues during the tissue repair process by biomaterials. Furthermore, designing biomaterials with such bioadaptability would open a new door for repairing and regenerating organs or tissues. In this review, we summarized the works in recent years on the bioadaptability of biomaterials for tissue repair applications.
【作者單位】： National
【基金】：supported by the National Basic Research Program of China (No. 2012CB619100)
【分類號】：R318.08

【相似文獻】

相關期刊論文 前10條

1 魏寬海,裴國獻,胡罷生;A new approach to tissue repair:gene therapy[J];Chinese Journal of Traumatology;2000年04期

2 陳崢嶸;Progress of peripheral nerve repair[J];Chinese Journal of Traumatology;2002年06期

3 董宇啟,張鐘元,劉中遠;TREATMENT OF DISLOCATION OF THE FRESH ACROMIOCLAVICULAR JOINT USING INTERNAL FIXATION OF CLOSED REDUCTION AND CANNULATED LAG SCREW[J];Journal of Shanghai Second Medical University;1999年02期

4 程凱敏 ,朱政鳴 ,唐文淵 ,湯先榮;Decalcificated human dentin matrix in autogenous repair of skull defects[J];Chinese Journal of Traumatology;2001年04期

5 馬達 ,薛克修;Application of bone decom pression in the treatment and repair of affected lower limbers after osteochondrosis of tibial tuberosity[J];中國臨床康復;2002年06期

6 鐘前進;The repair of Ebstein's anomaly with ventricular unloading[J];China Medical Abstracts;2005年03期

7 Howard J. Leonhardt;Michael Brown;;Myoblast transplantation for heart repair:A review of the state of the field[J];Journal of Geriatric Cardiology;2006年03期

8 Jonathan Dinsmore;Nabil Dib;;Myoblast transplantation can repair heart damage[J];Journal of Geriatric Cardiology;2006年03期

9 ;Bone marrow mesenchymal stem cells and spinal cord injury repair[J];Neural Regeneration Research;2012年16期

10 Stefano Geuna;Pierluigi Tos;Bruno Battiston;;Emerging issues in peripheral nerve repair[J];Neural Regeneration Research;2012年29期

相關會議論文 前10條

1 Hamid Rabb;;Temporal and site-specific trafficking receptors expression on regulatory T cells during repair from ischemic acute kidney injury[A];中華醫(yī)學會第十七次全國兒科學術大會論文匯編（下冊）[C];2012年

2 ;Anomalous origin of the left coronary aartery from pulmonary artery:ten years experiences in diagnosis and surgical repair[A];第二屆長三角超聲醫(yī)學論壇暨2009年浙江省超聲醫(yī)學學術年會論文匯編[C];2009年

3 ;Anomalous origin of the left coronary artery from pulmonary artery-Ten years experiences in diagnosis and surgical repair[A];中華醫(yī)學會第十次全國超聲醫(yī)學學術會議論文匯編[C];2009年

4 Bingqing Huang;Juying Qian;Jianying Ma;Zheyong Huang;Yunli Shen;Xueying Chen;Aijun Sun;Junbo Ge;Haozhu Chen;;Transfection of Hypoxia-Inducible Factor-1a enhances mesenchymal stem cells-mediated cardiac repair in rats with experimental myocardial infarction[A];中華醫(yī)學會第十五次全國心血管病學大會論文匯編[C];2013年

5 Jianhong Zhu;;Regenerative medicine focus on brain and nerve repair[A];細胞—生命的基礎——中國細胞生物學學會2013年全國學術大會·武漢論文摘要集[C];2013年

6 Lijian Lo;;△113p53/△133p53 switches p53 signal pathway from repressing to promoting DNA double strand break repair[A];2012全國發(fā)育生物學大會摘要集[C];2012年

7 ;Model and Simulation of Minimum Leave Window Creating Under the Cluster Munition Assaults[A];Proceedings of 2010 Chinese Control and Decision Conference[C];2010年

8 ;Mismatch repair system(mutS and mutL) in Acinetobacter bayiyi ADP1[A];2012全國臨床微生物與感染免疫學術研討會論文集[C];2012年

9 ;Comparative study of transverse preputial island flap used for hypospadias repair between primary surgery and reoperation[A];華東六省一市泌尿外科學術年會暨2011年浙江省泌尿外科、男科學學術年會論文匯編[C];2011年

10 池麗平;蔡勖;;Complex networks under the attack and repair strategy[A];第二屆全國復雜動態(tài)網絡學術論壇論文集[C];2005年

相關重要報紙文章 前2條

1 閻皓;漂漂亮亮老照片[N];中國電腦教育報;2003年

2 飛翔;雙重加密 仍遭“黑”[N];電腦報;2005年

相關博士學位論文 前1條

1 馬文;漢語會話中的照應修正研究[D];上海外國語大學;2004年

相關碩士學位論文 前4條

1 張偉;[D];西安外國語大學;2016年

2 邵宇;中國刑事法庭審判話語中的修正特點及成因研究[D];華中師范大學;2014年

3 張少林;高中英語課堂教師對學生話語修正的語用研究[D];湖南科技大學;2010年

4 田莉莉;中國外語學習環(huán)境下師生互動二人組合模式研究[D];廣東外語外貿大學;2014年

，

本文編號：2124395